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• Thus, our data show that PB2 amino acids 627 and 701 are determinants of mammalian inter-host transmission in diverse virus backgrounds. accuracy algorithm alignment annotation antibody archaea architecture assembly avian bacterial bayesian bifc binding biofuel bioinformatics bootstrap bret bsi cancer cellcycle chaperone chromatin chromosome clade clustering co-evolution co-extinction coil collaboration comparativegenomics compensatory complex computational confidence contact cooccurrence counter cpg-island culture database degradation deletion design differentiation disease divergence diversity dna docking domain drug duplication dynamics ecoli ecology element em emulation endogenous epigenetics epistasis epitope eukaryota evolution experiment expression fitness fluorescent folding fret function gene geneexpression genefamily geneontology generegulation genetic genetics genome genome-wide hemagglutinin hgt hierarchical histone hiv hla hmm homology homologymodeling hostspecialization hub human immunity immunohistochemistry influenza information-theory insilico integration interaction interface invitro invivo lgt likelihood linker localization magnetic mammal massspectrometry mathematic membrane metabolism methylation mhc mi microarray microrna modeling module molecularrecognition morphological motif mp mrp mutation nanopore nanoscale nature ncrna neoselection network neural nmr noise nuclear oligonucleotide oral ortholog pathobiology pathway pca peptide phenotype phosphorylation phylogeny phylogeography plant polymerase positiveepistasis positiveselection prediction presentation profile prokaryote promoter protection protein proteomics protocol purification qtl regulation regulatory reliability research residue reverse-engineering review ribosome ribozyme rna rnasep rule sampling science secondary selection sequence similarity simulation singlecell singlemolecule site sites social speciation specy stability statistical structure substitution subunit surface svm synthetic system systematic tag tap target technique text-mining theory threading tissue tlr transcription translation transmembrane trna vesicle viability video virus visualization web y2h yeast ysd —  CiteULike: Everyone's library
• Using an empirical quality control framework presented in Venkatesan et al., also online, the data set is evaluated for quality and is used to estimate the total size of the worm interactome. accuracy algorithm alignment annotation antibody archaea architecture assembly avian bacterial bayesian bifc binding biofuel bioinformatics bootstrap bret bsi cancer cellcycle chaperone chromatin chromosome clade clustering co-evolution co-extinction coil collaboration comparativegenomics compensatory complex computational confidence contact cooccurrence counter cpg-island culture database degradation deletion design differentiation disease divergence diversity dna docking domain drug duplication dynamics ecoli ecology element em emulation endogenous epigenetics epistasis epitope eukaryota evolution experiment expression fitness fluorescent folding fret function gene geneexpression genefamily geneontology generegulation genetic genetics genome genome-wide hemagglutinin hgt hierarchical histone hiv hla hmm homology homologymodeling hostspecialization hub human immunity immunohistochemistry influenza information-theory insilico integration interaction interface invitro invivo lgt likelihood linker localization magnetic mammal massspectrometry mathematic membrane metabolism methylation mhc mi microarray microrna modeling module molecularrecognition morphological motif mp mrp mutation nanopore nanoscale nature ncrna neoselection network neural nmr noise nuclear oligonucleotide oral ortholog pathobiology pathway pca peptide phenotype phosphorylation phylogeny phylogeography plant polymerase positiveepistasis positiveselection prediction presentation profile prokaryote promoter protection protein proteomics protocol purification qtl regulation regulatory reliability research residue reverse-engineering review ribosome ribozyme rna rnasep rule sampling science secondary selection sequence similarity simulation singlecell singlemolecule site sites social speciation specy stability statistical structure substitution subunit surface svm synthetic system systematic tag tap target technique text-mining theory threading tissue tlr transcription translation transmembrane trna vesicle viability video virus visualization web y2h yeast ysd —  CiteULike: Everyone's library
• We demonstrated the advantages of PINA by analyzing two human PPI networks; our results suggested a link between LKB1 and TGFbeta signaling, and revealed possible competitive interactors of p53 and c-Jun. accuracy algorithm alignment annotation antibody archaea architecture assembly avian bacterial bayesian bifc binding biofuel bioinformatics bootstrap bret bsi cancer cellcycle chaperone chromatin chromosome clade clustering co-evolution co-extinction coil collaboration comparativegenomics compensatory complex computational confidence contact cooccurrence counter cpg-island culture database degradation deletion design differentiation disease divergence diversity dna docking domain drug duplication dynamics ecoli ecology element em emulation endogenous epigenetics epistasis epitope eukaryota evolution experiment expression fitness fluorescent folding fret function gene geneexpression genefamily geneontology generegulation genetic genetics genome genome-wide hemagglutinin hgt hierarchical histone hiv hla hmm homology homologymodeling hostspecialization hub human immunity immunohistochemistry influenza information-theory insilico integration interaction interface invitro invivo lgt likelihood linker localization magnetic mammal massspectrometry mathematic membrane metabolism methylation mhc mi microarray microrna modeling module molecularrecognition morphological motif mp mrp mutation nanopore nanoscale nature ncrna neoselection network neural nmr noise nuclear oligonucleotide oral ortholog pathobiology pathway pca peptide phenotype phosphorylation phylogeny phylogeography plant polymerase positiveepistasis positiveselection prediction presentation profile prokaryote promoter protection protein proteomics protocol purification qtl regulation regulatory reliability research residue reverse-engineering review ribosome ribozyme rna rnasep rule sampling science secondary selection sequence similarity simulation singlecell singlemolecule site sites social speciation specy stability statistical structure substitution subunit surface svm synthetic system systematic tag tap target technique text-mining theory threading tissue tlr transcription translation transmembrane trna vesicle viability video virus visualization web y2h yeast ysd —  CiteULike: Everyone's library
• Conclusion: As having been validated on the majority of known structural families, this method should prove useful for the detection of active sites in any protein with unknown function, and for direct application to the design of site-directed mutagenesis experiments. accuracy algorithm alignment annotation antibody archaea architecture assembly avian bacterial bayesian bifc binding biofuel bioinformatics bootstrap bret bsi cancer cellcycle chaperone chromatin chromosome clade clustering co-evolution co-extinction coil collaboration comparativegenomics compensatory complex computational confidence contact cooccurrence counter cpg-island culture database degradation deletion design differentiation disease divergence diversity dna docking domain drug duplication dynamics ecoli ecology element em emulation endogenous epigenetics epistasis epitope eukaryota evolution experiment expression fitness fluorescent folding fret function gene geneexpression genefamily geneontology generegulation genetic genetics genome genome-wide hemagglutinin hgt hierarchical histone hiv hla hmm homology homologymodeling hostspecialization hub human immunity immunohistochemistry influenza information-theory insilico integration interaction interface invitro invivo lgt likelihood linker localization magnetic mammal massspectrometry mathematic membrane metabolism methylation mhc mi microarray microrna modeling module molecularrecognition morphological motif mp mrp mutation nanopore nanoscale nature ncrna neoselection network neural nmr noise nuclear oligonucleotide oral ortholog pathobiology pathway pca peptide phenotype phosphorylation phylogeny phylogeography plant polymerase positiveepistasis positiveselection prediction presentation profile prokaryote promoter protection protein proteomics protocol purification qtl regulation regulatory reliability research residue reverse-engineering review ribosome ribozyme rna rnasep rule sampling science secondary selection sequence similarity simulation singlecell singlemolecule site sites social speciation specy stability statistical structure substitution subunit surface svm synthetic system systematic tag tap target technique text-mining theory threading tissue tlr transcription translation transmembrane trna vesicle viability video virus visualization web y2h yeast ysd —  CiteULike: Everyone's library
• The proposed method can be used in other research areas, such as DNA-binding site prediction, protein-protein interaction, and prediction of posttranslational modification sites. accuracy algorithm alignment annotation antibody archaea architecture assembly avian bacterial bayesian bifc binding biofuel bioinformatics bootstrap bret bsi cancer cellcycle chaperone chromatin chromosome clade cloning clustering co-evolution co-extinction coil collaboration comparativegenomics compensatory complex computational confidence contact cooccurrence counter cpg-island culture database degradation deletion design differentiation disease divergence diversity dna docking domain drug duplication dynamics ecoli ecology element em emulation endogenous enzyme epigenetics epistasis epitope eukaryota evolution experiment expression fitness fluorescent folding fret function gene geneexpression genefamily geneontology generegulation genetic genetics genome genome-wide hemagglutinin hgt hierarchical histone hiv hla hmm homology homologymodeling hostspecialization hub human immune immunity immunohistochemistry influenza information-theory insilico integration interaction interface invitro invivo lgt likelihood linker localization m2 magnetic mammal massspectrometry mathematic membrane metabolism methylation mhc mi microarray microrna modeling module molecularrecognition morphological motif mp mrp mutation nanopore nanoscale nature ncrna neoselection network neural nmr noise np nuclear oligonucleotide oral ortholog pathobiology pathway pca peptide phenotype phosphorylation phylogeny phylogeography plant polymerase positiveepistasis positiveselection prediction presentation profile prokaryote promoter protection protein proteomics protocol purification qtl regulation regulatory reliability replication research residue reverse-engineering review ribosome ribozyme rna rnasep rule sampling science secondary selection sequence similarity simulation singlecell singlemolecule site sites social speciation specy stability statistical structure substitution subunit surface svm synthetic system systematic tag tap target technique text-mining theory threading tissue tlr transcription translation transmembrane trna vesicle viability video virus visualization web y2h yeast ysd —  CiteULike: Everyone's library

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