Definitions
from The American Heritage® Dictionary of the English Language, 5th Edition.
- noun Any of a group of enzymes that catalyze the hydrolysis of sulfate esters and are found in animal tissues and bacteria.
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun biochemistry Any of several
enzymes , inanimals andbacteria , whichcatalyze thehydrolysis oforganic sulfates .
Etymologies
from The American Heritage® Dictionary of the English Language, 4th Edition
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Examples
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"A canine Arylsulfatase G (ARSG) mutation leading to a sulfatase deficiency is associated with neuronal ceroid lipofuscinosis"
innovations-report 2010
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-- On November 25, 2009 - Ipsen announced the initiation of an international, multi-center, controlled, randomized Phase II clinical trial to evaluate the safety and efficacy of BN83495, its investigational first-in-class steroid sulfatase (STS) inhibitor, in advanced endometrial cancer.
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Our results uncover a protein involved in neuronal homeostasis, identify a family of candidate genes to be screened in patients with Kufs 'disease, and suggest that a deficiency in sulfatase is part of the NCL pathogenesis.
innovations-report 2010
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More information: "A canine Arylsulfatase G (ARSG) mutation leading to a sulfatase deficiency is associated with neuronal ceroid lipofuscinosis", Published: Aug. 17, 2010, in
PhysOrg.com - latest science and technology news stories 2010
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-- On December 14, 2009 - Ipsen announced the preliminary results of a phase I trial in metastatic breast cancer with BN83495, Ipsen's lead and first-in-class orally available irreversible steroid sulfatase (STS) inhibitor.
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In transfected cells or leukocytes from affected dogs, the missense change leads to a 75% decrease in sulfatase activity, providing a functional confirmation that the variant might be the NCL-causing mutation.
innovations-report 2010
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The aromatase and sulfatase projects were started at HWI by Dr. Yoshio Osawa more than 30 years ago.
YubaNet.com 2009
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The other two enzyme structures determined by the Ghosh lab as part of this project were estrone sulfatase (2003) and 17beta-hydroxysteroid dehydrogenase type 1 (1996).
YubaNet.com 2009
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Ipsen (Paris: IPN) today announced the initiation of an international, multi-center, controlled, randomized Phase II clinical trial to evaluate the safety and efficacy of BN83495, its investigational first-in-class steroid sulfatase (STS) inhibitor, in advanced endometrial cancer.
THE MEDICAL NEWS 2009
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His preliminary work laid the foundation for the eventual solution of the structure of estrone sulfatase.
YubaNet.com 2009
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