sulfoximine

We added to class I HDACIs the glutathione-synthesis inhibitor buthionine sulfoximine (BSO), in an attempt to create an intracellular environment that would facilitate HIV-1 activation.

BioMed Central - Latest articles Andrea Savarino 2009

To test this hypothesis, we evaluated the HIV-1 activating effects of buthionine sulfoximine (BSO), which depletes glutathione by inhibiting γ-glutamyl cysteine synthetase (a limiting step in glutathione synthesis) [27, 30].

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Stimulation of HIV-1 LTR-controlled expression of green fluorescent protein (GFP) by MS-275 and buthionine sulfoximine (BSO), alone or in combination in a Jurkat cell clone (A1).

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\ "Shock and kill\" effects of class I-selective histone deacetylase inhibitors in combination with the glutathione synthesis inhibitor buthionine sulfoximine in cell line models for HIV-1 quiescence Retrovirology 2009, 6: 52 doi: 10.1186/1742-4690-6-52 Andrea Savarino

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Effects on HIV-1 replication and cell viability of class I-selective HDACIs, MS-275 and buthionine sulfoximine (BSO), alone or in combination.

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We added to class I HDACIs the glutathione-synthesis inhibitor buthionine sulfoximine (BSO), in an attempt to create an intracellular environment that would facilitate HIV-1 activation.

Recently Uploaded Slideshows mabasta 2009

Stereoselective pharmacokinetics of L-buthionine SR-sulfoximine in patients with cancer.

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"Shock and kill" effects of class I-selective histone deacetylase inhibitors in combination with the glutathione synthesis inhibitor buthionine sulfoximine in cell line models for HIV-1 quiescence Andrea Savarino*1§ Antonello Mai, * 2 Sandro Norelli1, Sary El Daker1, Sergio Valente,2 Dante Rotili,2 Lucia Altucci,3 Anna Teresa Palamara2,5 and Enrico Garaci6.

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