“A 2005 study of radiotherapy and a drug called temozolomide found that 27% of patients lived more than two years and nearly 20% lived past three years -- more than twice the typical survival time.”
“The researchers, based at hospitals in Europe and Canada, gave patients both radiation and a chemotherapy drug called temozolomide for six weeks; patients then continued taking the drug alone five days a month for the following six months.”
“Currently, a drug called temozolomide is the first-line treatment for glioblastoma in humans.”
“The study cohort was divided into 2 groups, those with and without receiving post-radiotherapy adjuvant chemotherapy such as temozolomide or nitrosourea-based chemotherapy.”
“Patients with metastatic melanoma often are treated off-label with drugs such as temozolomide, which has been approved by the FDA for the treatment of certain types of brain cancer but not for the treatment of metastatic melanoma.”
“The median survival in the radiation plus temozolomide group was 14.6 months compared to 12.1 months in the radiation alone group.”
“The trial with temozolomide was conducted by the European Organization for Research and Treatment of cancer and The National cancer Institute of Canada and presented to American Society of Clinical Oncology (ASCO).”
“The current standard of care for malignant gliomas is surgical resection and radiotherapy followed by extended adjuvant treatment with the alkylating agent temozolomide.”
“Through changes in the DNA-repair machinery, glioma cells develop resistance to temozolomide, compromising the therapeutic effect of the drug.”
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