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thiazolidinedione

Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. Any of a class of drugs, used to treat diabetes, containing a five-membered heterocyclic ring containing a nitrogen and a sulfur atom and two carbonyl groups.

Etymologies

Sorry, no etymologies found.

Examples

  • Another recent study suggests that diabetics who are being treated with thiazolidinedione, an antidiabetic drug, provided “further evidence of a possible association between long-term use of thiazolidinediones and fractures, particularly of the hip and wrist, in patients with diabetes mellitus.”

    Forever Young

  • On December 12, 2007, JAMA reported another population-based study by Canadian researchers of patients 66 and older with diabetes, that found thiazolidinedione treatment, primarily with Avandia, was associated with an increased risk of congestive heart failure, acute myocardial infarction, and mortality when compared with other combination oral hypoglycemic agent treatments.

    Government Estimates 83,000 Excess Heart Attacks Caused By Avandia

  • The Committee points out that Dr Buse is an expert in diabetes with extensive research experience in the thiazolidinedione class of drugs that includes Avandia and states: "Corporate intimidation, the silencing of scientific dissent, and the suppression of scientific views threaten both the public well-being and the financial health of the federal government, which pays for health care."

    Government Estimates 83,000 Excess Heart Attacks Caused By Avandia

  • Unfortunately, as the head of one endocrinology department at a leading university medical school put it to me, an alarming number of patients are dropping out of ongoing clinical trials involving rosiglitazone and other thiazolidinedione drugs thanks to the media and congressional circus over Avandia.

    Trevor Butterworth: Medical Journal Malpractice?

  • After factoring in the potential effects of other risk factors, the investigators found that the use of any thiazolidinedione was associated with a 59% increased risk of cancer, but there was an 89% increased risk associated with Avandia.

    Studies Find More Health Risks With Avandia

  • "This suggests that thiazolidinedione treatment is a risk factor and can contribute to excess incidence of fractures in diabetes," the researchers wrote in the study.

    Studies Find More Health Risks With Avandia

  • Bear Stearns analyst Mark Schoenebaum said physicians whom Bear Stearns spoke with "were not shy about discussing their off-label use of Byetta," particularly with thiazolidinedione, or TZD.

    Amylin Investors Advised To Buy On Weakness

  • It is indicated for the treatment of type 2 diabetes as a monotherapy and in combination with metformin, a sulphonylurea, a thiazolidinedione or insulin.

    Reuters: Press Release

  • Pioglitazone is a thiazolidinedione or TZD, marketed by Takeda as ACTOS

  • As per the study's results, after taking a thiazolidinedione (TZD) for one year, women are

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