American Heritage® Dictionary of the English Language, Fourth Edition
- n. A protease in blood that facilitates blood clotting by converting fibrinogen to fibrin.
Century Dictionary and Cyclopedia
- n. The fibrin ferment which causes the coagulation of the blood; thrombase.
- n. biochemistry An enzyme in blood that facilitates blood clotting by converting fibrinogen to fibrin (by means of ionized calcium).
GNU Webster's 1913
- n. (Biochem.) The enzyme which converts fibrinogen into fibrin.
- n. an enzyme that acts on fibrinogen in blood causing it to clot
“In its natural state, the aptamer binds with an enzyme called thrombin, which regulates blood clotting.”
“The newer drug works on one protein in the coagulation cascade called thrombin - "which is right at the blood clot, the one right at the end of this process," Sharma says.”
“One, Pradaxa, a so-called direct thrombin inhibitor, was approved late last year by the U.S. Food and Drug Administration.”
“Known as a direct thrombin inhibitor, it was superior to and safer than warfarin at one dose but a trend toward a survival benefit in a major study wasn't statistically significant.”
“But even with aggressive antiplatelet therapy, more than 10% of treated patients suffer heart attacks, prompting a quest to develop anticoagulants to fight another major contributor to clots: the enzyme thrombin.”
“Pradaxa acts by inhibiting thrombin, an enzyme in the blood that is involved in blood clotting.”
“Angiotech enters license, distribution and supply agreements for fibrin and thrombin technologies with Haemacure Corporation.”
“Platelet aggregation and fibrin formation both require the proteolytic enzyme thrombin, plus calcium ions and about a dozen other protein clotting factors.”
“Another Factor Xa inhibitor,apixaban, is in trials as is a direct thrombin inhibitor,dabigatran.”
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