Definitions
from The American Heritage® Dictionary of the English Language, 5th Edition.
- noun A long-acting sulfonylurea drug, C12H18N2O3S, used to treat non-insulin-dependent diabetes.
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun A drug that blocks
potassium channels , used in the treatment ofdiabetes .
from WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.
- noun sulfonylurea; an oral antidiabetic drug (trade name Orinase) used in the treatment of adult-onset diabetes mellitus
Etymologies
from The American Heritage® Dictionary of the English Language, 4th Edition
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Examples
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Metformin and sulfonylurea drugs -- the latter a class of diabetes drugs including glyburide, glipizide, chlorpropamide, tolbutamide and tolazamide -- are often among the first medications prescribed to lower blood sugar levels in people with type 2 diabetes.
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In time, the reputation of the class of diabetic drugs to which tolbutamide belonged was salvaged to some degree by proposing that tolbutamide might interfere with a purported pathophysiologic mechanism called "ischemic preconditioning" while others drugs in this family might not.
Whole new ball game-case in point Avandia james gaulte 2007
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Data presented indicated that tolbutamide increased cardiovascular deaths by over two and a half times.
Archive 2007-06-01 james gaulte 2007
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Data presented indicated that tolbutamide increased cardiovascular deaths by over two and a half times.
Whole new ball game-case in point Avandia james gaulte 2007
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In time, the reputation of the class of diabetic drugs to which tolbutamide belonged was salvaged to some degree by proposing that tolbutamide might interfere with a purported pathophysiologic mechanism called "ischemic preconditioning" while others drugs in this family might not.
Archive 2007-06-01 james gaulte 2007
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Inform patient that alcohol may react with tolbutamide and cause Antabuse - like reaction (eg, flushing, headache, dizziness, high BP).
Wii-volution 2010
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Type 2 diabetes that went through a strikingly similar controversy: tolbutamide.
NYT > Home Page By DAN HURLEY 2010
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The headline appeared almost exactly 35 years ago, on July 4, 1975, about a different drug for Type 2 diabetes that went through a strikingly similar controversy: tolbutamide.
Top Headlines 2010
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Kangkong showed oral hypoglycaemic activity in tests with diabetic humans and rats; it was shown that an aqueous leaf extract can be as effective as tolbutamide in reducing blood glucose levels
Find Me A Cure 2009
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Clinically meaningful interactions would not be expected with other sulfonylureas (e.g., glipizide, tolbutamide, and glimepiride) which, like glyburide, are primarily eliminated by CYP2C9.
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