Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- adjective biology Extending across a
lesion , often specifically a damaged section ofDNA
Etymologies
from Wiktionary, Creative Commons Attribution/Share-Alike License
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Examples
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Zhuang's five-year, $783,000 award will support an integrated research and outreach program focusing on the development of new chemical methods for efficiently bonding ubiquitin, the so-called "kiss of death" protein, to proliferating cell nuclear antigen (PCNA), a key protein in DNA replication and repair, and exploring at the molecular level how cells bypass damaged DNA in a process called translesion synthesis.
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Zhuang's five-year, $783,000 award will support an integrated research and outreach program focusing on the development of new chemical methods for efficiently bonding ubiquitin, the so-called "kiss of death" protein, to proliferating cell nuclear antigen (PCNA), a key protein in DNA replication and repair, and exploring at the molecular level how cells bypass damaged DNA in a process called translesion synthesis.
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"Currently we are working to dissect the different steps in the process of translesion synthesis with a focus on the role of ubiquitin modification," Zhuang says.
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Zhuang's team has been investigating the molecular mechanism of translesion synthesis in the model organism
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Self-poisoning of Mycobacterium tuberculosis by targeting GlgE in an α-glucan pathway Chemically ubiquitylated PCNA as a probe for eukaryotic translesion DNA synthesis Dioxygenases catalyze the O-demethylation steps of morphine biosynthesis in opium poppy A combined method for producing homogeneous glycoproteins with eukaryotic N-glycosylation Self-poisoning of Mycobacterium tuberculosis by targeting GlgE in an α-glucan pathway
Naturejobs - All Jobs Michael Lammers 2010
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Zhuang's team has been investigating the molecular mechanism of translesion synthesis in the model organism
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Zhuang's team has been investigating the molecular mechanism of translesion synthesis in the model organism Saccharomyces cerevisiae (more commonly known as baker's yeast or budding yeast), which has proven to be extremely useful in understanding many essential cellular processes in eukaryotes, the domain of life that includes higher-order organisms such as humans, animals, and plants.
THE MEDICAL NEWS Editors 2010
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"Currently we are working to dissect the different steps in the process of translesion synthesis with a focus on the role of ubiquitin modification," Zhuang says.
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Johnson RE, Prakash L, Prakash S (2006) Yeast and human translesion DNA synthesis polymerases: expression, purification, and biochemical characterization.
PLoS ONE Alerts: New Articles Rodrigo Vasquez-Del Carpio et al. 2009
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The structure we present here is the first for a eukaryotic translesion synthesis (TLS) DNA polymerase with an 8-oxoG: A base pair in the active site.
PLoS ONE Alerts: New Articles Rodrigo Vasquez-Del Carpio et al. 2009
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