Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. Any of a family of antifungal antibiotics that are histone deacetylase inhibitors

Etymologies

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Examples

  • The expression of IL6 is also reduced in RASFs treated with trichostatin A and ultrasound [26].

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  • A.L.B. designed and performed the RNAi screen, all validation experiments, quantitative RT-PCR, generation of stable cell lines and studies on cyclosporin, cholesterol and trichostatin.

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  • For the new study, Dr Arafat and her colleagues compared the anti-inflammatory properties of thymoquinone with trichostatin A, a known HDAC inhibitor previously reported to improve inflammation-associated cancers.

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  • Moreover, the effect was superior to that observed from trichostatin A.

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  • Thymoquinone almost completely abolished the expression of several inflammatory cytokines, including TNF-alpha, interleukin-1beta, interleukin-8, Cox-2 and MCP-1, an effect that was more superior to the effect of trichostatin A.

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  • This effect was superior to the effect of trichostatin A-- an inflammation inhibitor already shown to ameliorate inflammation-associated cancers.

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  • Based upon their previously published findings that thymoquinone inhibits histone deacetylases (HDACs), Dr. Arafat and her colleagues compared the anti-inflammatory properties of thymoquinone and trichostatin A, an HDAC inhibitor that has previously shown to ameliorate inflammation-associated cancers.

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  • A previous study showed a trend towards higher toxicity of the HDACI trichostatin in ACH-2 cells than in their uninfected counterparts and linked this phenomenon to the cytotoxicity of activated HIV-1 replication in lymphoid cells [16].

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  • • TSA, trichostatin A • HAT, histone acetyltransferase • HDAC, histone deacetylase • LPK, liver-type pyruvate kinase.

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  • Hypermethylation of the LARG promoter was not detected in either breast or colorectal cancer, and treatment of four breast and four colorectal cancer cell lines with 5-aza-2'-deoxycytidine and/or trichostatin A did not result in a reactivation of

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