ubiquitination love

Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. The modification of a protein by the covalent attachment of one or more ubiquitin molecules

Etymologies

Sorry, no etymologies found.

Examples

  • Are you claiming that ubiquitination is specific for lysine residues, or are you predicting that as a hypothesis that you are interested in testing?

    Death of a popular anti-ID argument

  • We continued and demonstrated that, unlike the paradigm in the field until that time, that degradation of proteins in the lysosome proceeds independently from the ubiquitin system - the two proteolytic pathways are actually linked to one another, and ubiquitination is required for stress-induced lysosomal degradation of cellular proteins.

    Aaron Ciechanover - Autobiography

  • Interestingly, the ligase involved in BSA ubiquitination is E3a that was discovered during my graduate studies.

    Aaron Ciechanover - Autobiography

  • This subject has evolved in a surprising manner and changed another paradigm in the field that ubiquitination is limited to internal lysine (s) of the target substrate; we, and later others, have shown that the phenomenon is not limited to the one protein we identified initially - the muscle-specific transcriptional regulator

    Aaron Ciechanover - Autobiography

  • This is typically managed through the process called ubiquitination, in which doomed proteins are chemically marked for entry into a degradation pathway by protein complexes known as ubiquitin ligases.

    innovations-report

  • This process, called ubiquitination, flags protein substrates for destruction but can also serve as a regulatory signal.

    PhysOrg.com - latest science and technology news stories

  • A while ago I had noticed that prediction of phosphorylation propensity could also predict ubiquitination and vice-versa.

    Archive 2009-06-01

  • In order to get there I will try first to develop some methods to predict ubiquitination and E3 targets.

    Open Science - just do it

  • Other studies involved elucidation of some of the mechanisms involved in the two step ubiquitin-mediated proteolytic activation of the centrally important transcriptional regulator NF-KB, demonstration of a role for heat shock proteins in targeting certain protein substrates, and identification of a novel site of ubiquitination - the N-terminal residue of the protein substrate.

    Aaron Ciechanover - Autobiography

  • In the latter case, the ligase binds to the N-terminal residue while ubiquitination occurs on an internal lysine residue (s).

    Aaron Ciechanover - Autobiography

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