from Wiktionary, Creative Commons Attribution/Share-Alike License
- n. A nonsteroidal anti-inflammatory drug formerly used to treat osteoarthritis, rheumatoid arthritis, and menstrual pain.
from WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.
- n. a Cox-2 inhibitor (trade name Bextra) that relieves pain and inflammation without harming the digestive tract
Sorry, no etymologies found.
Although medications that studies show posed the highest risk, including rofecoxib (Vioxx) and valdecoxib (Bextra), were banned or removed from the U.S. market, many NSAIDs with identified risks, such as prescription-only celecoxib (Celebrex), still are on the market.
They further pointed out in a press release alternatives such as rofecoxib and valdecoxib increase the rise of cardiovascular dysfunctions, including stroke.
According to Scientific American, Reuben “attempted to convince orthopedic surgeons to shift from the first generation of nonsteroidal anti-inflammatory drugs (NSAIDs) to the newer, proprietary COX2 inhibitors, such as Vioxx, Celebrex, and Pfizer's Bextra (valdecoxib).”
Both Merck and Pharmacia have second-generation Cox-2 inhibitors in the pipeline, at least one of which, Pharmacia's valdecoxib, may be on the market by early next year.
Bextra (valdecoxib), which was withdrawn from the market in 2005.
The COX-2 inhibitors were first linked to an increased risk of heart attack and other cardiovascular problems, and two of the drugs -- rofecoxib (Vioxx) and valdecoxib (Bextra) -- were pulled from the market in 2004 and 2005, respectively; a third COX-2 inhibitor, celecoxib
These packs can receive at any cnbc celebrex february 2007 during staff and without valdecoxib symptoms.
PMS program needs to include studies intended to 4: practolol, fenclofenac, feprazone, valdecoxib. 5: indoprofen, Osmosin. resolve any queries or questions that have been 6: nomifensine, remoxipride. noted in the animal safety evaluation studies or 7: zomepirac, Althesin. the earlier studies in man.
Both findings "are consistent with the idea that the vascular hazards of coxibs are greater in the presence of conditions predisposing to platelet activation, as was suggested by the early increase in risk associated with parecoxib and valdecoxib when these drugs were given immediately after coronary artery bypass grafting," say Baigent and Patrono.
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