from Wiktionary, Creative Commons Attribution/Share-Alike License
- n. An anticoagulant drug once proposed as a replacement for warfarin but withdrawn due to hepatotoxicity risks.
Sorry, no etymologies found.
An AstraZeneca PLC drug called ximelagatran came close, but failed when it proved toxic to the liver.
I had my hopes that ximelagatran would be the replacement for warfarin.
Lincoff told heartwire that, undoubtedly, hangovers from the ximelagatran experience were making people nervous.
The signal with ximelagatran "was clearly more frequent than any potential signal we are dealing with here, but the FDA wanted to be cautious," Lincoff notes.
The experience with ximelagatran had indicated that monotherapy with the drug was associated with higher early rates of recurrent VTE relative to warfarin, Schulman and colleagues wrote.
The researchers said no liver toxicity was seen with the drug, in contrast to another oral thrombin inhibitor, ximelagatran.
"We know that with warfarin and, to some extent, direct thrombin inhibitors like ximelagatran, more potent anticoagulation can reduce those events, but, as with all effective anticoagulants, they increase bleeding."
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