Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. An analysis of allelic association for genes throughout a genome.

Etymologies

from Wiktionary, Creative Commons Attribution/Share-Alike License

Acronym of genome-wide association study

Examples

  • Last question, just a clarification here again, kind of GWAS, not putting words in your mouth but sounds nothing large there really going on, cytogenetics growing rapidly.

    SeekingAlpha.com: Home Page

  • The awful lesson from this is that the more tightly you manage things the odder the unanticipated consequences on May 18, 2009 at 6: 08 am GWAS Medic

    The First Of The Gang To Die. « POLICE INSPECTOR BLOG

  • Dennis Drayna, a geneticist at the National Institutes of Health, sympathized with Goldstein, even though he was waist-deep in GWAS himself.

    The $1,000 Genome

  • New York Times: and 454 successes, 17; Goldstein GWAS comments in, 62; Martin comment about X Prize in, 233; Quake article in, 123, 222; Rienhoff quote in, 39; Rubin comment about Sanger method in, 93; Stoicescu comment in, 208; and 23andMe launch, 33

    The $1,000 Genome

  • But by the year 2000, the number had climbed to 1 million, and the idea of conducting genome-wide association studies GWAS for complex diseases like diabetes and heart disease became serious.

    The $1,000 Genome

  • Studies by Helen Hobbs at the University of Texas Southwestern Medical Center showed that targeted sequencing could identify such “Goldilocks” variants.12 But some scientists thought Goldstein went too far, arguing that the value of GWAS is not so much in predicting personal disease susceptibility as in identifying likely disease pathways.

    The $1,000 Genome

  • GWAS could facilitate much quicker paths from gene to drug, as deCODE once demonstrated in moving from heart-disease genes spotted by GWAS to a drug in clinical trials in just two years.

    The $1,000 Genome

  • Stephan, who suspected that many of the reported GWAS results were tantamount to garbage, attached great importance to the triage process.

    The $1,000 Genome

  • This is a prerequisite for most GWAS papers in the major journals.

    The $1,000 Genome

  • Taken together, the plummeting cost of genotyping and the ensuing GWAS bounty made the personal-genomics era possible.

    The $1,000 Genome

Comments

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  • Perlegen was now in a position to design a DNA chip with several hundred thousand markers and begin to do genome-wide association studies (GWAS). These are essentially very dense case-control studies designed to find DNA markers important in disease. By typing the same set of markers in large numbers of cases and controls, it becomes a brute-force statistical matter of finding markers that pop up more frequently in sick people than in healthy ones. Those markers are very likely to be in or near genes that play a role in disease.

    GWAS studies have since become ho-hum. But only a few years ago, they were the new new thing.

    Misha Angrist, Here is a Human Being: At the Dawn of Personal Genomics (New York: HarperCollins, 2010), ch. 4 (Kindle loc. 1046)

    December 17, 2016