Definitions

from The American Heritage® Dictionary of the English Language, 5th Edition.

  • adjective Of or involving a change in the shape and activity of an enzyme that results from molecular binding with a regulatory substance at a site other than the enzymatically active one.

from Wiktionary, Creative Commons Attribution/Share-Alike License.

  • adjective biochemistry, of an enzyme That binds a compound on an inactive site and thus changes conformation in order to become either active or inactive

Etymologies

from Wiktionary, Creative Commons Attribution/Share-Alike License

allo- (“other”) +‎ steric (“arrangement of atoms in space”)

Examples

  • Under the agreement, Addex will regain rights to intellectual property and know-how and can pursue the program independently. www.addexpharma.com discovers and develops an emerging class of small molecule drugs, called allosteric modulators, which have the potential to be more specific and confer significant therapeutic advantages over conventional "orthosteric" small molecule or biological drugs.

    Reuters: Press Release

  • In contrast to some of its rivals, Addex has a relatively wide portfolio of new products and a novel technology platform known as allosteric modulation, factors which analysts say make it a potential star of the Swiss biotech sector.

    Reuters: Top News

  • In contrast to some of its rivals, Addex has a relatively wide portfolio of new products and a novel technology platform known as allosteric modulation, factors which analysts say make it a potential star of the Swiss biotech sector.

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  • In contrast to some of its rivals, Addex has a relatively wide portfolio of new products and a novel technology platform known as allosteric modulation, factors which analysts say make it a potential star of the Swiss biotech sector.

    Reuters: Top News

  • The researchers have discovered that apamin binds away from the channel pore, and causes the shape of the channel to change through an 'allosteric' mechanism, resulting in block.

    PhysOrg.com - latest science and technology news stories

  • As an essential feature, interactions among the components of a system have effects (technically 'allosteric' effects) that help organize and coordinate its processes, allowing the self-replication to proceed.

    Citizendium, the Citizens' Compendium - Recent changes [en]

  • As an essential feature, interactions among the components of a system have effects (technically 'allosteric' effects) that help organize and coordinate its processes, allowing the self-replication to proceed.

    Citizendium, the Citizens' Compendium - Recent changes [en]

  • From these measurements we calculated all of the equilibrium constants of the "allosteric" cycle as follows: diliganded gating, unliganded gating, dissociation from the C (losed) conformation, and dissociation from the O (pen) conformation.

    Journal of Biological Chemistry current issue

  • Scientists already know that a family of 'allosteric' drugs can switch off this enzyme but until now no-one knew how they worked.

    Medlogs - Recent stories

  • Most genetic control mechanisms are based on an "allosteric" molecule that both senses the problem and acts in response to the information.

    Yahoo! Answers: Latest Questions

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