from The American Heritage® Dictionary of the English Language, 5th Edition.

  • adjective Situated in front of or occurring before a synapse.

from Wiktionary, Creative Commons Attribution/Share-Alike License.

  • adjective cytology in a synapse, of or pertaining to the neuron that releases neurotransmitter into the synaptic cleft


from Wiktionary, Creative Commons Attribution/Share-Alike License

pre- + synaptic


  • The lack of an effect of the serine-413 mutation of RIM1α is not due to compensation by RIM2α because mice carrying both the serine-413 substitution and a RIM2α deletion still exhibited normal long-term presynaptic plasticity.

    Proceedings of the National Academy of Sciences current issue

  • Thus, phosphorylation of serine-413 of RIM1α is not essential for PKA-dependent long-term presynaptic plasticity

    Proceedings of the National Academy of Sciences current issue

  • Locally it blocks the initiation and propagation of nerve impulses along an axon by interference with sodium permeability during depolarization. 3,11 Centrally it blocks the presynaptic reuptake of norepinephrine and dopamine.

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  • Platelet bioamines in blood, urine or saliva for NE norepinephrine, Dopamine and Serotonin, Melatonin, Acetylcholine, GABA should reflect NMDA induction and depletion of presynaptic inhibitory neurotransmitters.


  • Generally, neurotoxins affecting neurotransmission act to increase or decrease the release of a neurotransmitter at the presynaptic membrane, block receptors at the postsynaptic membrane, or modify the inactivation process of the neurotransmitter.


  • Synthesis and storage of neurotransmitter in the presynaptic knob of axon


  • Given that neurons 'activity depends partly upon their total input, and total input depends partly on synaptic weights (e.g., presynaptic neurotransmitter release rate, number and efficacy of postsynaptic receptors, availability of enzymes in synaptic cleft), the capacity of biological networks to change their synaptic weights make them plastic vector-to-vector transformers.

    The Philosophy of Neuroscience

  • For example, Eric Kandel (1976) proposed presynaptic mechanisms governing transmitter release rate as a cell-biological explanation of simple forms of associative learning.

    The Philosophy of Neuroscience

  • At electrical synapses, the current generated by the action potential at the presynaptic neuron flows directly into the postsynaptic cell, which is physically connected to the presynaptic terminal by a so-called gap junction.

    Quantum Approaches to Consciousness

  • There are presynaptic dopaminergic receptors which, when stimulated by dopamine, inhibit its own release.

    LANC Chair Elections - Senator Brady Westwater


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