Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. An arrow with a barbed tip.
  • n. A sequence of amino acids that forms a motif, in FOX proteins, that binds to DNA

Etymologies

from Wiktionary, Creative Commons Attribution/Share-Alike License

From fork +‎ head.

Examples

  • When the proteins, called forkhead box transcription factors, were removed in young mice, oxidative stress increased and bone weakness developed.

    Newswise: Latest News

  • The FOXA1 marker, also known as forkhead box A1, is a gene known to cause breast cancer.

    Headlines - Inside INdiana Business with Gerry Dick

  • The protein that is encoded by this gene is of a class called 'forkhead transcription factors', which act to control the expression of other genes.

    RedOrbit News - Technology

  • The FOXL2 forkhead transcription factor is expressed in ovarian granulosa cells, and mutated

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  • Bentsi-Barnes IK, Barlow GM, Bae J, Pisarska MD (2009) Sumoylation of forkhead L2 by Ubc9 is required for its activity as a transcriptional repressor of the Steroidogenic Acute Regulatory gene.

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  • Ellsworth BS, Burns AT, Escudero KW, Duval DL, Nelson SE, et al. (2003) The gonadotropin releasing hormone (GnRH) receptor activating sequence (GRAS) is a composite regulatory element that interacts with multiple classes of transcription factors including Smads, AP-1 and a forkhead DNA binding protein.

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  • Crisponi L, Deiana M, Loi A, Chiappe F, Uda M, et al. (2001) The putative forkhead transcription factor FOXL2 is mutated in blepharophimosis/ptosis/epicanthus inversus syndrome.

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  • Although the importance of the forkhead transcription factor FOXL2 in ovarian development and function is established, regulation of its action is not well understood.

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  • As a forkhead transcription factor with a primary role in follicle and eyelid development, the importance of FOXL2 in ovarian development and function is unquestioned, but its expression is under complex transcriptional control

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  • In particular, FOXL2 represses the expression of the StAR promoter, which harbours 15 potential forkhead-responsive recognition motifs, in CHO

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Comments

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  • An arrow with a barbed head.

    September 30, 2008