from The American Heritage® Dictionary of the English Language, 4th Edition
- n. The protein constituent of hemoglobin and myoglobin.
from Wiktionary, Creative Commons Attribution/Share-Alike License
- n. One of several polypeptides that are the protein components of haemoglobin in blood.
from the GNU version of the Collaborative International Dictionary of English
- n. a colorless protein obtained by removing heme from hemoglobin; the protein part of hemoglobin.
from The Century Dictionary and Cyclopedia
- n. The proteid substance which with hematin makes up the larger part of the red blood-corpuscles. It is possibly a mixture of several distinct proteids.
from WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.
- n. a colorless protein obtained by removing heme from hemoglobin; the oxygen carrying compound in red blood cells
The normal expression of human beta globin is highly dependent upon the stability of its encoding mRNA.
If no or badly functioning beta-globin is made, the life-span of the red blood cells is shortened resulting in anemia.
Had we used other substrates, such as globin, the protein we used in our initial experiments, the E3 adsorbed to the column would have probably escaped our attention, as E3s do not typically adsorb to ubiquitin.
Despite its importance, relatively little is known about the structural determinants of beta-globin mRNA stability or how they contribute to regulating beta-globin gene expression.
Sickle cell disease is caused by one mutation in a gene for the beta globin chain, which is one of the two major chains (alpha and beta chains) that make up the adult hemoglobin molecule.
This project is designed to establish a comprehensive understanding of the structures, factors and mechanisms that affect the stability of human beta-globin mRNA. This information promises to be helpful in designing therapies for sickle cell disease.
Novel approaches to increase gamma-globin expression in sickle cell disease
We offer a broad test menu, with analysis of over 40 different genes for more than 30 genetic disorders, including craniosynostosis syndromes, neurogenetic/developmental disorders, globin genes and clotting disorders, and cancer predisposition syndromes.
Isolation and nucleotide sequence analysis of the beta-type globin pseudogene from human, gorilla and chimpanzee.
A human makes 300 billion red blood cells every day, each loaded with globin proteins that carry oxygen through the body.