from The American Heritage® Dictionary of the English Language, 4th Edition
- n. An ATP-generating metabolic process that occurs in nearly all living cells in which glucose is converted in a series of steps to pyruvic acid.
- n. The metabolic breakdown of glucose and other sugars that releases energy in the form of ATP.
from Wiktionary, Creative Commons Attribution/Share-Alike License
- n. The cellular degradation of the simple sugar glucose to yield pyruvic acid, and ATP as an energy source.
from The Century Dictionary and Cyclopedia
- n. The destruction of sugar in the animal body.
from WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.
- n. a metabolic process that breaks down carbohydrates and sugars through a series of reactions to either pyruvic acid or lactic acid and releases energy for the body in the form of ATP
Meyerhof's greatest achievement was his ability to clarify both the starring and supporting roles of the many molecules involved in glycolysis and then place them in proper sequence of the metabolic script.
Meyerhof was convinced that an active form of hexosemonophosphate was an intermediate in glycolysis and associated with the formation of pyruvate.
Answering such questions was a challenge because most of the components involved in glycolysis were typified by a very transient existence, making them difficult to isolate, much less analyze, test and then place in proper sequence.
The understanding of the individual reactions in glycolysis grew geometrically.
The unravelling of its structure and bioenergetic role in glycolysis clearly stands out as a major scientific accomplishment.
Although ATP plays a critical role in glycolysis, it is only one actor among many in a very large production.
In addition to spawning Meyerhof's first doubts about the centrality of lactic acid in glycolysis, the discovery encouraged him to begin measurements of the amount of energy released by the splitting of the bonds of creatine phosphate and other phosphate derivatives.
Parnas soon postulated a phosphate cycle, whereby the use of one ATP for phosphorylation is balanced by regeneration of ATP during subsequent steps in glycolysis.
Meyerhof and Hill's pioneering thermodynamic studies had been the basis for the conclusion that the cycle of lactic acid formation and oxidation were the key events in glycolysis.
One of most important advances of the decade involved painstaking work that helped demonstrate that the formation of esters from carbohydrates is indeed an intermediate reaction in glycolysis.