Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. The molecular framework responsible for a drug's biological activity.

Etymologies

Sorry, no etymologies found.

Examples

  • A pharmacophore is a set of structural features in a molecule that is recognized at a receptor site.

    Forever Young

  • As for cinnamic aldehyde, the curcuminoids, and the nitroalkenes, I believe the anticancer activity and other therapeutic benefits of a nitrone spin trap results from the fact that it is a mild electrophile and a Michael acceptor pharmacophore.

    Forever Young

  • When phytonutrients and other molecules that contain the Michael acceptor–like pharmacophore upregulate the transcription factor NRF2, more than a dozen protective anti-inflammatory proteins in the cell are activated.

    Forever Young

  • The paper notes that the MCSS is not necessarily of biochemical relevance, indicating that there is room for pharmacophore like concept in the CDK.

    Archive 2007-01-01

  • At the conference, Addex will disclose a novel oral mGluR4 PAM chemical scaffold with a pharmacophore and structure activity relationship that is completely different from existing molecules in the field.

    Reuters: Press Release

  • Subsequently we will derive inverted pharmacophore models for the binding modes observed.

    Naturejobs - All Jobs

  • The pharmacophore models may then be use to select compound libraries that are enriched with features desirable for

    Naturejobs - All Jobs

  • * Design and synthesis of SERCA inhibitors base don the pharmacophore of thapsigargin.

    Naturejobs - All Jobs

  • This includes e.g. compound selection for screening, low to medium-throughput docking, pharmacophore identification and use,

    Naturejobs - All Jobs

  • Winssinger and co-workers focused their attention on the unique RAL pharmacophore, as various

    innovations-report

Comments

Log in or sign up to get involved in the conversation. It's quick and easy.