from The American Heritage® Dictionary of the English Language, 4th Edition

  • n. A colorless or pale yellow oily liquid, C10H10O2, derived from oil of sassafras and other essential oils and used in making perfume and soap.

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. A colourless to yellow liquid, a component of sassafras oil and brown camphor oil, with pesticidal properties.


from The American Heritage® Dictionary of the English Language, 4th Edition

French safran, saffron; see saffron + -ole.


  • Many foods also contain carcinogens -- chemicals that cause cancer at high dose in laboratory animals -- such as safrole in cinnamon.

    Chemicals, Cancer And Claptrap

  • The main aromatic in hoja santa is safrole, the characteristic note of sassafras familiar from root beers, and a suspected carcinogen.

    On Food and Cooking, The Science and Lore of the Kitchen

  • The recipe requires oil of sassafras, or another source of safrole.


  • Nutmeg is more dangerous ingested, but safrole rubbed in to the skin is something else...

    The Guardian World News

  • A spokeswoman 288 litres of safrole oil has been seized, enough to make 2.3 million ecstasy tablets. | Top Stories

  • In July 2008, in Pursat, 170km west of Cambodian capital Phnom Penh, UN anti-drug officers destroyed 30 tons of safrole-rich oil, which was to be used by clandestine chemists in Holland to make ecstasy, using Shulgin's recipe.

    Home | Mail Online

  • For ecstasy, this involved safrole, an essential oil produced by distilling the root bark of certain trees.

    Home | Mail Online

  • It was also revealed Australian Customs alerted police to the arrival of the machines into Australia with the raids taking place following a seven month multi-agency investigation into cocaine supply and safrole oil manufacture. The Northern Star

  • During the raids police also seized ecstasy pills, LSD, cannabis, cocaine, steroids, and safrole oil (the precursor to MDMA). The Northern Star

  • - This vanilla-like safrole derivative is not a nutritional phytochemical, but is being studied for its relaxing properties in aromatherapy.



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  • "The pulse of dance-club music plays like a jungle beat, as thumping bass notes flirt with flashing lights, liquor and ecstasy of the pharmaceutical kind. Miles and miles away, a little-known multi-billion dollar battle is playing out in the remote wilderness of Cambodia, linking the club scene to the jungle in a more nefarious way. Clandestine factories deep in the Cardamom Mountains of western Cambodia are producing safrole oil — also known as sassafras oil — the main ingredient in the party drug Ecstasy."

    - Sam Campbell, Harvested to make Ecstasy, Cambodia's trees are felled one by one,, 30 August 2009.

    September 7, 2009