Definitions

from The American Heritage® Dictionary of the English Language, 4th Edition

  • n. A basic, long-chain, unsaturated amino alcohol, C18H37NO2, found combined with lipids in the brain and in nerve tissue.

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. An unsaturated aliphatic amino alcohol associated with the lipids of brain tissue

Etymologies

German Sphingosin : Greek sphingos, genitive of sphinx, sphinx (from the mysteries it presented to early observers) + -ine2.
(American Heritage® Dictionary of the English Language, Fourth Edition)

Examples

  • Gilenya (fingolimod), licensed from Mitsubishi Tanabe Pharma Corporation, is the first in a new class of drugs that modulates sphingosine 1-phosphate (S1P) receptors[1],[2].

    Reuters: Press Release

  • The contribution of DNL-derived FA to ceramide synthesis was evaluated based on deuterium labeling of sphingosine - and acyl-groups (D), whereas non-DNL derived FA is illustrated with a blue column on the bottom of each bar.

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  • In addition, our data show that DNL contributed relatively less stearoyl - than sphingosine-moiety to muscle c18 ceramide, suggesting that low SCD1 activity in muscle could be responsible for the increased dependency of muscle ceramide accumulation on dietary fat.

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  • The results clearly show that both the sphingosine and fatty-acyl groups of liver c16 ceramide were mostly derived from DNL, whereas those of muscle c18 ceramide were derived from non-DNL sources, presumably dietary lipids.

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  • Molecular fragments and ions of acyl - and sphingosine groups in TMS-derivatized ceramides (A) and their mass spectra (B).

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  • Figure 7D, the extent of isotopic labeling in the sphingosine and fatty-acyl groups of ceramide molecules was analyzed, where f1 denotes fatty acids incorporated into the sphingosine group, while f2 and f3 denote fatty acids incorporated into the fatty-acyl groups of hepatic c16 ceramide and muscular c18 ceramide, respectively.

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  • Wada A, Igarashi Y (2002) N-glycans of sphingosine 1-phosphate receptor Edg-1 regulate ligand-induced receptor internalization.

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  • Chiossone L, Chaix J, Calver A, Carozzo C, et al. (2007) Natural killer cell trafficking in vivo requires a dedicated sphingosine 1-phosphate receptor.

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  • Effect of CD treatment on free sphingosine levels in NPC mice

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  • Early chronic CD treatment normalized the free sphingosine level in brain of the 22-day old

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  • "Used in the Same Context: anaplastic · creatine · diphosphate · extracellular · haematopoietic · histidine · myosin"

    April 13, 2011