thrombospondin love

Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. Any of a group of secreted glycoproteins with antiangiogenic properties

Etymologies

from Wiktionary, Creative Commons Attribution/Share-Alike License

Coined in a 1972 paper by Baenziger et al., named due to its sensitivity to thrombin.

Examples

  • The molecule that works this magic is a protein called thrombospondin-1, or TSP1, suggesting that this particular offensive guard might be a potent drug for saving heart-attack victims; restoring blood flow in patients with severe diabetes, in which impaired blood flow leads to gangrene; and treating hypertension.

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  • Through cell culture and mouse experiments, the researchers found that a protein called thrombospondin-1 (TSP1) and its receptor, CD47, inhibit activation of the endothelial-based enzyme called endothelial nitric oxide synthase (eNOS), which in turn limits the production of

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  • In addition, a very intense repression of THBS1 (thrombospondin 1) was observed.

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  • TGF-β1 also regulates the behaviour of keratinocytes by inducing the expression of various ECM proteins such as tenascin, thrombospondin, fibronectin, vitronectin, collagen and several proteoglycans etc.

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  • Adamts5 (a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2)) was found in UD

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  • C. elegans resembles thrombospondin, the protein secreted by glia in vertabrates, the researchers suggest that the glia-neuron relationships observed in chance

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  • With respect to gonadal function, Adamts19 (a disintegrin and metalloproteinase domain, with thrombospondin type-1 modules), significantly up-regulated in 20\% CR, 40\% CR and HFG diets, has been shown to be expressed in multiple tissues, and in particular the testes

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  • Katsube K, Michikawa M, Yamada M, Takada S, et al. (2004) R-spondin, a novel gene with thrombospondin type 1 domain, was expressed in the dorsal neural tube and affected in Wnts mutants.

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  • There are four human paralogs (R-spondin1-4), each containing a leading signal peptide, two cystein-rich, furin-like domains, and one thrombospondin type 1 domain.

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  • Furthermore, we show in mice and in human cartilage explants that pharmacological or genetic inhibition of Hh signaling reduces the severity of osteoarthritis and that runt-related transcription factor-2 (RUNX2) potentially mediates this process by regulating a disintegrin and metalloproteinase with thrombospondin type 1 motif-5 (ADAMTS5) expression.

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