Daubenton used ipecacuanha . . . restricting his dose from a quarter of a grain to two grains, just sufficient to occasion a slight vermiculatory motion in the stomach, but he only gave it once in the twenty-four hours, in the morning fasting.
--John Forbes, Alexander Tweedie, John Conolly and Robley Dunglison, 1848, The Cyclopaedia of Practical Medicine, p. 638