Downregulation love

Definitions

from The American Heritage® Dictionary of the English Language, 4th Edition

  • The mainland part of Equatorial Guinea, on the Bight of Biafra in western Africa.

Etymologies

Sorry, no etymologies found.

Examples

  • Porteu F, Sanchez E, Nathan CF (1990) Downregulation of tumor necrosis factor receptors on macrophages and endothelial cells by microtubule depolymerizing agents.

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  • Downregulation of XIAP resulted in activation of caspase-3 and caspase-9 to trigger apoptosis in glioma cells.

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  • Downregulation of MMP-9, uPAR, and CB inhibited matrigel invasion, in vitro angiogenesis and wound-healing migration ability of PC3 and DU145 prostate cancer cell lines.

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  • Downregulation of BMI1 by Mel-18 overexpression or knockdown of BMI1 expression in gastric cancer cell lines led to upregulation of p16 (p16INK4a or CDKN2A) in p16 positive cell lines and reduction of phospho-AKT in both p16-positive and p16-negative cell lines.

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  • Downregulation of BMI1 was also accompanied by decreased transformed phenotype and migration in both p16 - positive and p16-negative gastric cancer cell lines.

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  • Chibalin AV, Leng Y, Vieira E, Krook A, Bjornholm M, et al. (2008) Downregulation of diacylglycerol kinase delta contributes to hyperglycemia-induced insulin resistance.

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  • Figure 4: Downregulation of APT1 increases the steady-state palmitoylation level of Ras.

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  • Downregulation of miR-132 is consistent with our finding that preconditioning ischemia induces a rapid increase in MeCP2 protein, but not mRNA, in mouse cortex.

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  • Chow JM, Liu CR, Lin CP, Lee CN, Cheng YC, et al. (2008) Downregulation of c-Myc determines sensitivity to 2-methoxyestradiol-induced apoptosis in human acute myeloid leukemia.

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  • Downregulation of these receptors with age explanations for all such perceived differences.

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