from The American Heritage® Dictionary of the English Language, 4th Edition
- n. Any of several diseases of the blood or lymph vessels.
from Wiktionary, Creative Commons Attribution/Share-Alike License
- n. Any disease of the blood vessels.
from the GNU version of the Collaborative International Dictionary of English
- n. Disease of the vessels, esp. the blood vessels.
from The Century Dictionary and Cyclopedia
- n. Disease of the lympathics or blood-vessels.
from WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.
- n. any disease of the blood vessels or lymph ducts
Instead, it resembles a form of human Alzheimer's disease, cerebral amyloid angiopathy, that damages brain arteries.
Evidence indicates that soluble forms of amyloid-beta (Abeta) are vasoactive, which may contribute to cerebrovascular dysfunction noted in patients with Alzheimer's Disease and cerebral amyloid angiopathy.
Cerebral amyloid angiopathy (CAA) refers to the deposition of b - amyloid in the media and adventitia of small - and mid-sized arteries (and less frequently, veins) of the cerebral cortex and the leptomeninges.
Although the benefits of anticlotting medications in patients at risk for MI or ischemic stroke outweigh any risks of bleeding, the researchers said, microbleeding risk may influence treatment for some patients, such as those with signs of cerebral amyloid angiopathy.
Location appears to be important: strictly lobular microbleeding suggests cerebral amyloid angiopathy, in which accumulation of amyloid protein leads to degeneration of smooth muscle cells and increases risk of ruptures and hemorrhages.
When microbleeds occur in certain brain areas, they may indicate a type of small vessel disease known as cerebral amyloid angiopathy, in which the accumulation of amyloid (a protein often related to Alzheimer's disease) causes degeneration of smooth muscle cells and increases the susceptibility of blood vessels to ruptures and hemorrhages.
"Nevertheless, it may be that in selected persons (e.g., those with signs of cerebral amyloid angiopathy), this risk-benefit ratio may differ for certain drugs (e.g., aspirin), thus influencing treatment decision," they conclude.
Clinical phenotypes of cerebral amyloid angiopathy.
 Rosand J, Hylek EM, O'Donnell HC, et al. Warfarin-associated hemorrhage and cerebral amyloid angiopathy: a genetic and pathologic study.
Figure 2 Surgical specimens from the matrix of a hematoma associated with amyloid angiopathy.
Wordnik is becoming a not-for-profit! Read our announcement here.