American Heritage® Dictionary of the English Language, Fourth Edition
- n. An enzyme isolated from bacteria that catalyzes the hydrolysis of asparagine and is used in the chemotherapeutic treatment of leukemia.
- n. biochemistry An enzyme that catalyzes the hydrolysis of asparagine to aspartic acid, used in chemotherapy.
- n. antineoplastic drug (trade name Elspar) sometimes used to treat lymphoblastic leukemia
- asparagine + -ase (Wiktionary)
“Health Canada's safety assessment of the enzyme, which is called asparaginase, didn't turn up any health or safety concerns.”
“When a 12-year-old boy from Illinois with ALL arrived at St. Jude in 2001, Pui administered everything but the kitchen sink: the drugs prednisone, vincristine, daunorubicin, and asparaginase, followed by cyclophosphamide, cytarabine, and mercaptopurine.”
“Put simply, the kids are blasted with the highest doses of the most chemotherapy drugs they can stand — steroids and vinca alkaloids, asparaginase and anthracyclines and more.”
“Graspa is an experimental therapy that consists of red blood cell-encapsulated L-asparaginase, an enyzme used to treat leukemia by damaging cancer cells.”
“By encapsulating the enzyme inside red blood cells, the company is seeking to make Graspa safer and have a broader range of clinical uses as compared to existing forms of L-asparaginase.”
“We're very interested in studying GRASPA® because of its reported reduction of L-asparaginase side effects.”
“L-asparaginase (randomized) allowed to compensate for this disadvantage; in high-risk patients (HR, 15 %), substitution of intensive polychemotherapy blocks for conventional BFM backbone failed to improve results.”
“Once susceptible batches are uncovered, the potato processing industry could ditch the guilty potatoes. asparaginase.”
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