from The American Heritage® Dictionary of the English Language, 4th Edition
- n. A bitter crystalline compound, C10H12O4, that is the active ingredient of cantharides and produces blistering of the skin.
from Wiktionary, Creative Commons Attribution/Share-Alike License
- n. A volatile organic compound in cantharis, or Spanish fly.
from the GNU version of the Collaborative International Dictionary of English
- n. The active principle of the cantharis, or Spanish fly, a volatile, acrid, bitter solid, crystallizing in four-sided prisms.
from The Century Dictionary and Cyclopedia
- n. A peculiar poisonous substance (C5H6O2) existing in the Cantharis vesicatoria (Spanish fly) and other insects, and causing vesication.
Sorry, no etymologies found.
As soon you took it in your hand, your body heat and the moisture on your fingers activated the cantharidin and you started to blister.
“The card was infused with a fluid called cantharidin, concentrated cantharidin,” she continued.
The method has also proved valuable in a great many ways in research into the constitution of complex natural products; these include the resinic acids and cantharidin, the active substance - with very peculiar chemical properties - of the "Spanish fly" (which is actually a beetle).
Hot water will now dissolve out _picrotoxin_, _colchicin_, and _digitalin_, but not cantharidin.
Jaua said the possibility "remains open" that arsenic prescribed as a medical treatment was a factor, or perhaps cantharidin, a compound which despite being toxic was consumed by some at the time.
PP2A, PP4 or PP5 may have to be considered as additional targets in the synergistic cooperation with proteasome inhibitors, since they all are inhibited by cantharidin, and have been implicated in contributing to apoptosis regulation
The salubrinal / cantharidin-sensitive phosphatase activity nevertheless seemed to be required to maintain viability in the face of extended proteasome inhibition and when this activity was blocked, cell viability was reduced or lost.
Neither cantharidin nor okadaic acid can inhibit activities of this phosphatase.
This notion is also supported by the observation that substitution of salubrinal with subtoxic concentrations of the phosphatase inhibitor cantharidin induced a comparable increase in PSI-mediated cytotoxicity, whereas the PP2B / calcineurin inhibitor cypermethrin proved to be ineffective.
This concentration of cantharidin is well below the reported IC50 for growth inhibition of various tumor cell lines
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