- n. a diuretic (trade names Hygroton and Thalidone) used to control hypertension and conditions that cause edema; effective in lowering blood pressure to prevent heart attacks
“For patients who have a systolic blood pressure 20 mm Hg or more over the target, either a thiazide-like diuretic -- such as chlorthalidone -- or a calcium channel blocker should be added.”
“I'm curious why the anonymous pharmacist doesn't like a drug that works, is dirt-freaking cheap, and has evidence of benefit for people with DM, CKD, and CHF and has pretty good blood-lowering ability in it's own right and is then combined with the drug recommended by JNC7admittedly I think that may change with JNC8 and go to either chlorthalidone OR an ACE-I as first-line, which is of course what lisinopril, the denigerated drug, is.”
“In fact, the chlorthalidone patients suffered less heart failure, stroke and angina than those receiving the newer, costlier drugs.”
“In late 2002, a huge study known as ALLHAT found that a diuretic (chlorthalidone), a calcium channel blocker (amlodipine) and an angiotensin-converting-enzyme (ACE) inhibitor (lisinopril) all had similar effects on heart-attack risk and overall mortality.”
“During the semifinals, Newcombe was confused about chlorthalidone, a diuretic used to treat hypertension.”
“CHICAGO-Patients with systolic hypertension who were treated with the diuretic chlorthalidone for 4.5 years as part of a clinical trial had a significantly lower rate of death and a gain in life expectancy free from cardiovascular death about 20 years later compared to patients who received placebo, according to a study in the December 21 issue of”
“The researchers obtained long-term mortality data for participants in the Systolic Hypertension in the Elderly Program (SHEP) trial, which was a randomized, placebo-controlled, clinical trial designed to assess the effect of antihypertensive drug treatment (chlorthalidone) in reducing the risk of stroke in patients with isolated systolic hypertension.”
“In 1991 SHEP found that low-dose chlorthalidone in 4,736 elderly patients with isolated systolic hypertension reduced the incidence of stroke and major cardiovascular events at 5 years.”
“The safety and efficacy of azilsartan medoxomil was studied for initial therapy as a once-daily oral monotherapy or in combination with other antihypertensive medications, including chlorthalidone and amlodipine, and was also studied in comparison to olmesartan medoxomil, valsartan and ramipril.”
“More than 33,000 patients with high blood pressure were randomly assigned to take either a diuretic (chlorthalidone) or one of two newer drugs, a calcium channel blocker (amlodipine) or an ACE inhibitor (lisinopril).”
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