“2006 Jan 25;: 1-12, MT, Wagner, K, Delaney, DP, and Kolon, TF Gene expression alterations in cryptorchid males using spermatozoal microarray analysis ..”
“Molecular research (microarray of RNA) from the sperm of cryptorchid men to identify novel genes associated with poor seminal parameters.”
“Microarray results on 10 control patients (mean age 28.5 yrs) and 12 cryptorchid males (mean age 18.3 years; 8 unilateral, 4 bilateral).”
“This large database has allowed physicians and researchers at The Children's Hospital of Philadelphia to gain a deeper understanding of the cryptorchid testis and its impact on future fertility and cancer.”
“Mean sperm density was significantly decreased between control, unilateral and bilateral cryptorchid samples (110 vs. 80 vs. 16 million/cc, p = 0.05).”
“Of these, 38 genes were significantly under-expressed in the cryptorchid samples including many transcriptional factors (cul3, prm1, hspcd35).”
“An apoptotic gene (TNF-alpha induced protein 3) was highly over-expressed (p = 0.001) in the cryptorchid samples suggesting a role for apoptosis as a cause for poor sperm densities.”
“The castration of a true cryptorchid requires a special operation.”
“In examining a supposed cryptorchid colt, he should be twitched.”
“Beigel, in Virchow's Archives, mentions a cryptorchid of twenty-two who had nocturnal emissions containing spermatozoa and who indulged in sexual congress.”
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