Definitions

from The American Heritage® Dictionary of the English Language, 4th Edition

  • n. A localized region on the surface of an antigen that is capable of eliciting an immune response and of combining with a specific antibody to counter that response.

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. That part of a biomolecule (such as a protein) that is the target of an immune response

from WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.

  • n. the site on the surface of an antigen molecule to which an antibody attaches itself

Etymologies

epi- + Greek topos, place, spot.
(American Heritage® Dictionary of the English Language, Fourth Edition)

Examples

  • This recombinant protein was used since deletion of the internal epitope between amino acids 433 and 447, called epitope 1443, increases the production of neutralizing antibodies in mouse models of infection

    PLoS ONE Alerts: New Articles

  • T cell mimicry and epitope specificity of cross-reactive T cell clones from rheumatic heart disease.

    The Autoimmune Epidemic

  • Taking into account the circulating B cells and calculating the quantity of antibody per immunologically-distinct epitope, the conclusion was that an infant could mount a response to the antigens present in “10 000 vaccines”.

    On Thursday, the Legg report will be published along with...

  • Although these features are inconsequential for the use of DsRed as a reporter of gene expression, the usefulness of DsRed as an epitope tag is severely limited.

    Archive 2005-10-01

  • Unfortunately, this protein is an obligate tetramer, making it less suitable fur use as an epitope tag than PA-GFP.

    Archive 2005-10-01

  • HVTN said the vaccine candidate was a multi-epitope vaccine developed by Epimmune, a San Diego-based pharmaceutical company.

    ANC Daily News Briefing

  • The library's diversity is expected to result in antibodies against previously inaccessible target molecules and unique epitope coverage.

    Reuters: Press Release

  • All cTnI constructs were derived from the full-length rodent sequence and tagged with C-terminal Flag epitope (DYKDDDDK, Sigma) to distinguish the recombinant from the native cTnI; while, the Tm mutants were engineered into the full-length human Tm

    PLoS ONE Alerts: New Articles

  • G159D cTnC was subcloned into the pDC315 AdMax shuttle vector (Microbix Biosystems Inc.) with and without an HA (Hemagglutinin) epitope tag as previously described

    PLoS ONE Alerts: New Articles

  • There is no specific epitope through which the activity can be explained, and

    SeekingAlpha.com: Home Page

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