Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • adj. exterior to a synapse

Etymologies

Sorry, no etymologies found.

Examples

  • Memantine preferentially blocks extrasynaptic over synaptic NMDA receptor currents in hippocampal autapses.

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  • Pascual O, Gobbo S, Pozzan T, Haydon PG, et al. (2004) Neuronal synchrony mediated by astrocytic glutamate through activation of extrasynaptic NMDA receptors.

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  • G, et al. (2004) Neuronal synchrony mediated by astrocytic glutamate through activation of extrasynaptic NMDA receptors.

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  • "Our study shows an increase in the number of extrasynaptic NMDA receptors, shifting the balance between these opposing cellular mechanisms in animal models of early stages of Huntington's disease," Raymond says.

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  • Second, we have previously shown that reelin controls the surface mobility of both synaptic and extrasynaptic NR2B-containing NMDARs

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  • Reelin depletion significantly decreased the surface mobility of extrasynaptic NR2B-containing NMDARs

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  • Also recently, astrocytic glutamate release has been implicated in extrasynaptic activation of neuronal KAR

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  • One possible interpretation of these results would be the existence of extrasynaptic KARs that could only be activated by glutamate spillover resulting from synchronous activation of excitatory fibres.

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  • The mechanisms can include a depolarizing action of GABA (γ-aminobutyric acid), transient synaptic connections, extrasynaptic transmission, gap junction coupling and the presence of pacemaker-like neurons.

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  • The research team found that low doses of Memantine reduce extrasynaptic activity without impairing protective synaptic activity.

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