from The American Heritage® Dictionary of the English Language, 4th Edition
- adj. Of or relating to synapsis or a synapse: synaptic nerve endings; the synaptic phase in meiosis.
from Wiktionary, Creative Commons Attribution/Share-Alike License
- adj. Of or relating to a synapse—the junction between the terminal of a neuron and another cell.
- adj. Of or relating to a synapsis—the association of homologous maternal and paternal chromosomes during the initial part of meiosis.
from The Century Dictionary and Cyclopedia
- Of or pertaining to synapsis.
from WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.
- adj. (neuroscience) of or involving synapses
This work made it clear to me that mice offered a superb genetic system for examining the role of individual genes in synaptic modification on the one hand, and intact behavior - explicit memory storage - on the other.
Two decades after Ramón y Cajal's proposal, the physiologist Alexander Forbes suggested that memory is sustained not by changes in synaptic strength of the sort suggested by
We appreciated that we had a particularly good experimental preparation for examining, on the cellular level, the role of second-messenger pathways in synaptic transmission, synaptic plasticity, and memory storage.
From Arvid Carlsson's research we now know that Parkinson's disease is due to failure in synaptic release of dopamine.
A practical course, and the book that resulted from this course, marked the end of our primary focus on methodological problems, and allowed me to concentrate my efforts on understanding the role of ion channels in synaptic signalling at the molecular level.
A close examination of cellular changes associated with memory revealed an increase in the number of functional synapses, activation of key signaling molecules and an enhancement of short - and long-term synaptic processes that are crucial for learning and memory.
During development the Ube3A mice had less spontaneous excitatory activity, fewer dendritic spines, no long term synaptic depression and needed much stronger stimulation to cause long term strengthening of the synapses (longterm potentiation - LTP).
The present study is undertaken to investigate whether prolonged exposure of rat organotypic hippocampal slice cultures to UCB alters the induction of long-term synaptic plasticity.
Our results indicate that the proteolytic cleavage of NMDA receptor subunits by calpain may play a critical role in mediating the UCB-induced impairment of long-term synaptic plasticity in the hippocampus.
Nevertheless, our data do not allow us to rule out the possibility that the abnormal intracellular signaling events downstream of NMDA receptor activation are also involved in the establishment of UCB-induced impairment of hippocampal long-term synaptic plasticity.
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