from The American Heritage® Dictionary of the English Language, 4th Edition
- n. A statin, C 24H25FNO4·NA, that blocks the body's synthesis of cholesterol and is administered especially to individuals who are at risk for heart disease.
from Wiktionary, Creative Commons Attribution/Share-Alike License
- n. A drug of the statin class, used to treat hypercholesterolemia and to prevent cardiovascular disease.
from WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.
- n. least expensive statin drug (trade name Lescol); usually taken orally at bedtime
Patients who were initially randomized to fluvastatin or placebo in the 5 - to 6-year trial were offered open-label fluvastatin in a 2-year extension of the original study.
Previous data suggest that lipophilic statins such as fluvastatin and N-bisphosphonates such as zoledronic acid, both inhibitors of the mevalonate metabolic pathway, have anti-cancer effects in vitro and in patients.
A study from Japan using a cell culture assay system reported that inteferon plus fluvastatin inhibited hepatitis C virus more effectively than did inteferon plus ribaviran.
Although cardiac deaths and non-fatal MI seemed to be reduced, fluvastatin did not generally reduce rates of coronary intervention procedures or mortality.
After a mean follow-up of 5.1 years, fluvastatin lowered LDL cholesterol concentrations by 32%.
Risk reduction with fluvastatin for the primary endpoint [a heart attack, fatal or nonfatal - ss] ... was not significant, although there were fewer cardiac deaths or non-fatal MI ... in the fluvastatin group than in the placebo group.
Overall effects of fluvastatin were similar to those of statins in other populations.
About half were given the statin drug fluvastatin, or Lescol, and the other half got a fake pill.
A randomised, double blind, placebo controlled trial investigated whether fluvastatin reduced major adverse cardiac events in patients who had undergone successful percutaneous coronary intervention (with or without stenting).
To calculate the sample size needed to compare fluvastatin with placebo, it was assumed that the proportion of patients having major adverse cardiac events at three years without treatment would be 25%.
Wordnik is becoming a not-for-profit! Read our announcement here.