from The American Heritage® Dictionary of the English Language, 4th Edition
- n. Any of a class of lipid-lowering drugs that reduce serum cholesterol levels by inhibiting a key enzyme involved in the biosynthesis of cholesterol.
from Wiktionary, Creative Commons Attribution/Share-Alike License
- n. Any of a class of drugs (chiefly lactones or pyrroles) that lower the amount of cholesterol in the blood by inhibiting an enzyme involved in its biosynthesis.
from WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.
- n. a medicine that lowers blood cholesterol levels by inhibiting HMG-CoA reductase
It may be that someone who has had muscle pain from a statin is at a higher risk of muscle pain from ezetimibe, but there is currently no information about that.
A controversial study showing that the blockbuster cholesterol-lowering drug Vytorin failed to slow the buildup of artery plaques more than a cheaper statin is certain to provoke questions among heart patients taking Vytorin or its sister drug Zetia.
According to the New England Journal of Medicine, boosting HDL cholesterol with extended-release niacin (Niaspan) is a more effective way of slowing atherosclerosis in high-risk patients on long-term statin therapy than seeking additional LDL cholesterol reductions by adding ezetimibe.
Long-term statin use 'reduces risk of gallstones requiring surgery'
"In the last few years, a number of publications in medical journals have reported apparent symptoms of anxiety and major depression in patients upon long-term statin administration," says Amitabha Chattopadhyay at the Centre for Cellular and Molecular Biology in
In fact, long-term statin use appears unlikely to substantially increase or decrease overall cancer risk, the researchers noted.
For example, odds for endometrial tumors fell by 39 percent among long-term statin users, while the risk for melanoma dropped by 19 percent, the study found.
But the new 10-year study suggests that "even long-term statin use is unlikely to increase the risk of common cancers," according to lead researcher Eric J. Jacobs, strategic director of pharmacoepidemiology at the American Cancer Society.
Harvard Medical School rheumatologist and RA researcher Daniel H. Solomon, MD, MPH, says the fact that a reduction in osteoarthritis risk was seen in long-term statin users calls into question the rheumatoid arthritis findings.
But long-term statin use has been associated with a reduced risk of several cancers, including breast, prostate, lung, pancreas and liver - and now bowel.
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