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• Words I often hear at my workplace
We don't know much of each other. (And this is probably why we still like each other.)
Add a word you hear at your workplace, and increase the mistery.
(One at a time, as in a spy story.)cathemerality, phylogenetics, lead generation, acquisitions, haha response, barcode, arthur or martha ..., venti, pedagogically, symphony product, p and ls, recovery process and 100 more...
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Prolagus http://www.sciencedirect.com/science/article/pii/S0731708509004725 Jan 18, 2013
bilby *glances at St Louis* Mar 9, 2009
reesetee So the HAHA response isn't very funny, sionnach? Apr 22, 2008
Prolagus I'm very proud of my list now. Apr 22, 2008
sionnach HAHA response: the formation of (Human) Antibodies in response to treatment with a (therapeutic) Humanized Antibody.
Induction of a HAHA response is generally undesirable, as the antibodies formed usually have the potential to neutralize the effect of the treatment antibody. Much care is taken to engineer non-human characteristics out of the treatment antibody as far as possible (hence the term 'humanized antibody'), to minimize the chances of it being perceived as 'foreign', thereby triggering a HAHA response in the subject.
The potential for this kind of unwanted immunogenic response is a major concern in clinical tests to evaluate the potential therapeutic benefit of new designer antibodies. In addition to neutralizing treatment activity, it can have clinical sequelae that are actively harmful to the patient.
Detection and accurate quantification of a HAHA response is notoriously difficult.
This phrase comes up in every team meeting I attend. It gives me nightmares.
Apr 22, 2008