American Heritage® Dictionary of the English Language, Fourth Edition
- n. An antibody that is capable of causing the destruction or dissolution of red blood cells, bacteria, or other cellular elements.
- n. A substance that causes lysis.
Century Dictionary and Cyclopedia
- n. In physiol. chem., one of the hexon bases; a diamino acid of the composition C6H14N2O2, resulting on decomposition of most albumins, including the protamines. It is the mother-substance of the ptomaïne cadaverin.
- n. A substance, found in blood serum, which, when injected into the body of an animal, will cause the dissolution or destruction of cellular elements. Such lysins may be produced artificially by immunization with various cells in animals of different species, and are then lytic for the corresponding cells. Such bodies are the hemolysins, the leucolysins, endotheliolysins, etc.
- n. any substance (such as an antibody) or agent that can cause lysis
“By harnessing the power of nature's own antibiotics, scientists have engineered an enzyme known as a lysin that not only kills MRSA in mice but also works synergistically with antibiotics that were once powerless against the formidable organism.”
“And we call such a method analysis, as being a solution backwards (anapalin lysin).”
“By adding another fractional protein, lysin, the rats were made to thrive.”
“The difference is often greater when using weaker solutions than when using stronger dilutions of lysin.”
“To develop a functional lysin, Fischetti's team, including Anu Daniel and Chad Euler, a former postdoc and a senior graduate fellow in the lab, respectively, took advantage of the modular nature of lysins.”
“It's as if this chimeric lysin evolved on its own," says Fischetti.”
“Synergism between a novel chimeric lysin and oxacillin protects against infection by methicillin-resistant Staphylococcus aureus, A.u Daniel, Chad Euler, Mattias Collin, Peter Chahales, Kenneth Gorelick and Vincent A. Fischetti”
“Rockefeller University scientists have now overcome this barrier by engineering a lysin that not only kills multidrug-resistant Staphylococcus aureus (MRSA) in mice, but also works synergistically with traditional antibiotics that have long been shelved due to resistance.”
“They then tested the chimeric lysin - named chimeric lysin for staphylococci, or ClyS - to see if it would behave like one that had evolved in nature.”
“For the past five years, Vincent A. Fischetti, head of the Laboratory of Bacterial Pathogenesis and Immunology, and his colleagues have tried to clone a lysin that specifically targets staph, but they always ran into the same problem.”
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