from The American Heritage® Dictionary of the English Language, 4th Edition
- n. A gene that causes the transformation of normal cells into cancerous tumor cells, especially a viral gene that transforms a host cell into a tumor cell.
from Wiktionary, Creative Commons Attribution/Share-Alike License
- n. Any gene that contributes to the conversion of a normal cell into a cancerous cell when mutated or expressed at high levels.
from WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.
- n. a gene that disposes normal cells to change into cancerous tumor cells
* The term oncogene had been coined earlier by two NCI scientists, Robert Huebner and George Todaro, in 1969, although on scant evidence.
This phenomenon—like an addict feeding an addiction by ramping up the use of a drug—is called oncogene amplification.
It was termed an oncogene,* a gene capable of causing cancer.
Firstly, the normal cellular oncogene is hyperactive, and secondly the oncogene product is altered so that it can no longer be regulated in a normal way.
An oncogene was the opposite—not a missing signal, but a signal in overabundance.
The term oncogene was introduced in the middle of the 1960s to denote special parts of the genetic material of certain viruses.
In this study, Pten-loss-induced cellular senescence (PICS) was found to be distinct from another form of cellular senescence known as oncogene-induced senescence in that it did not cause cellular proliferation and DNA damage.
G12V in primary cells induces a permanent growth arrest called oncogene-induced senescence (OIS) that serves as a fail-safe mechanism against malignant transformation.
Cancer research has also found a gene, called oncogene AC, that is extremely sensitive to even small doses of radiation.
The current results by Dr. Levy and his colleagues were obtained from experiments that examined tumors caused by the Ras oncogene, which is responsible for many human cancers.
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