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The discovery of this link between the two mechanisms-phagocytosis (engulfing germs) and autophagy (housekeeping) - suggests that a common mechanism that triggers both processes individually also links them by using a common set of signals.
Unlike other chordates, lancelets are capable of phagocytosis, a digestive process in which individual cells consume food particles.
Bloomfield G, Balest A, Balbo A, Pergolizzi B, et al. (2008) Genome-wide transcriptional changes induced by phagocytosis or growth on bacteria in— PLoS ONE Alerts: New Articles
Finnemann SC, Rodriguez-Boulan E (1999) Macrophage and retinal pigment epithelium phagocytosis: apoptotic cells and photoreceptors compete for alphavbeta3 and alphavbeta5 integrins, and protein kinase C regulates alphavbeta5 binding and cytoskeletal linkage.— PLoS ONE Alerts: New Articles
The effects of PI3K inhibitors on L. pneumophila phagocytosis were examined as described previously— PLoS ONE Alerts: New Articles
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