American Heritage® Dictionary of the English Language, Fourth Edition
- n. A chronic disease marked by stiffness and inflammation of the joints, weakness, loss of mobility, and deformity.
- n. pathology A chronic and progressive disease in which the immune system attacks the joints. It is characterised by pain, inflammation and swelling of the joints, stiffness, weakness, loss of mobility and deformity. Tissues throughout the body can be affected, including the skin, blood vessels, heart, lungs, and muscles.
- n. a chronic autoimmune disease with inflammation of the joints and marked deformities; something (possibly a virus) triggers an attack on the synovium by the immune system, which releases cytokines that stimulate an inflammatory reaction that can lead to the destruction of all components of the joint
“Regulation of interleukin-1beta-induced chemokine production and matrix metalloproteinase 2 activation by epigallocatechin-3-gallate in rheumatoid arthritis synovial fibroblasts.”
“These drugs do help to stave off joint destruction, but in the process TNF blockers also cause rheumatoid arthritis and psoriasis patients to have several-fold-higher rates of lymphoma a type of cancer.”
“Individuals with rheumatoid arthritis or lupus who breathe in heavy particles of air pollution for a year or more face a 22-percent increase in their risk of dying from their autoimmune disease.”
“Scientists linked exposure to compounds such as vinyl chloride—used in making plastic pipes PVC, wire and cable coatings, and packaging materials—to a higher risk of developing mixed lupus, scleroderma, and rheumatoid arthritis in people.”
“And in 2006, a shocking study based on hospital data from thirty-four cities over a fourteen-year span would show that people with autoimmune inflammatory diseases such as rheumatoid arthritis RA and lupus are at a substantially increased risk of death when they are exposed to particulate air pollution, or soot, for a substantial period of time.”
“Physicians can then warn patients: In the Netherlands researchers are using a connect-the-dot approach to determine which patients who show signs of early joint pain and stiffness should be treated prophylactically for rheumatoid arthritis and which should not.”
“Anti-TNF therapy, which has been used most broadly to treat rheumatoid arthritis with hopes that it would prove to be the bright new promise for suffering patients, has turned out to pack a nasty surprise.”
“Rheumatologists, discovering that the root cause of rheumatoid arthritis was the body attacking and inflaming its own tissue, claimed arthritis, lupus, and all other joint-related autoimmune illnesses as rheumatologic disorders.”
“Pro-and antioxidant blood system in patients with rheumatoid arthritis and systemic lupus erythematosus.”
“In other rheumatoid arthritis patients, TNF therapy actually kick-starts new forms of autoimmunity that mimic multiple sclerosis, autoimmune hemolytic anemia, type 1 diabetes, lupus, and psoriasis.”
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