“Our research was untargeted, and the line of inquiry we had begun in the 1940s yielded new drug therapies for malaria (pyrimethamine), leukemia (6-mercaptopurine and thioguanine), gout (allopurinol), organ transplantation”
“Stimulated by this finding Elion and Hitchings continued their research which soon resulted in two new chemotherapeutic drugs, thioguanine (1950) and”
“Meanwhile, the pursuit of 6-MP, thioguanine, azathioprine and allopurinol had occupied 20 years.”
“We continued to synthesize derivatives of 6-MP and thioguanine and investigate structure-activity relationships (38-40).”
“This lead to the loss of antitumor activity, with the exception of the 2-amino-6-mercapto derivative, thioguanine, which we had previously found to have strong antimetabolic activity.”
“Life-threatening ways and assuming have supported observed as linkages of thioguanine-induced granulocytopenia and thrombocytopenia.”
“However, the COG trial with 401 patients enrolled, showed that a thioguanine, procarbazine, lomustine and vincristine (TPCV) regimen was more effective than the CV regimen and resulted in a five-year event-free survival rate of nearly”
“The study of 401 patients found that a regimen of thioguanine, procarbazine, lomustine and vincristine (TPCV) was more effective than a carboplatin and vincristine (VC) regimen and achieved a 5-year, event-free survival rate of almost 50 percent.”
“(as well as thioguanine) are still used in the treatment of leukemia (Table II).”
“(particularly by methylthioinosinic acid), inhibition of inosinate dehydrogenase, and the incorporation into DNA in the form of thioguanine (35).”
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