Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun organic chemistry A derivative of
guanine obtained by replacing thecarbonyl group with athiol ; it is anantineoplastic agent
from WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.
- noun an antineoplastic drug used to treat acute leukemias
Etymologies
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Examples
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Our research was untargeted, and the line of inquiry we had begun in the 1940s yielded new drug therapies for malaria (pyrimethamine), leukemia (6-mercaptopurine and thioguanine), gout (allopurinol), organ transplantation
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Stimulated by this finding Elion and Hitchings continued their research which soon resulted in two new chemotherapeutic drugs, thioguanine (1950) and
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We continued to synthesize derivatives of 6-MP and thioguanine and investigate structure-activity relationships (38-40).
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This lead to the loss of antitumor activity, with the exception of the 2-amino-6-mercapto derivative, thioguanine, which we had previously found to have strong antimetabolic activity.
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Meanwhile, the pursuit of 6-MP, thioguanine, azathioprine and allopurinol had occupied 20 years.
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Life-threatening ways and assuming have supported observed as linkages of thioguanine-induced granulocytopenia and thrombocytopenia.
Wii-volution 2010
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The study of 401 patients found that a regimen of thioguanine, procarbazine, lomustine and vincristine (TPCV) was more effective than a carboplatin and vincristine (VC) regimen and achieved a 5-year, event-free survival rate of almost 50 percent.
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The study of 401 patients found that a regimen of thioguanine, procarbazine, lomustine and vincristine (TPCV) was more effective than a carboplatin and vincristine (VC) regimen and achieved a 5-year, event-free survival rate of almost 50 percent.
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The study of 401 patients found that a regimen of thioguanine, procarbazine, lomustine and vincristine (TPCV) was more effective than a carboplatin and vincristine (VC) regimen and achieved a 5-year, event-free survival rate of almost 50 percent.
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However, the COG trial with 401 patients enrolled, showed that a thioguanine, procarbazine, lomustine and vincristine (TPCV) regimen was more effective than the CV regimen and resulted in a five-year event-free survival rate of nearly
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