American Heritage® Dictionary of the English Language, Fourth Edition
- n. Any of a group of antidepressant drugs, such as amitryptyline, that contain three fused benzene rings and that block the reuptake of the neurotransmitters norepinephrine and serotonin in the central nervous system.
- n. an antidepressant drug that acts by blocking the reuptake of norepinephrine and serotonin and thus making more of those substances available to act on receptors in the brain
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