from The American Heritage® Dictionary of the English Language, 4th Edition
- n. An alkaloid, C46H58N4O9, obtained from the Madagascar periwinkle and used as an antineoplastic drug.
from Wiktionary, Creative Commons Attribution/Share-Alike License
- n. A particular drug used in chemotherapy.
from WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.
- n. periwinkle plant derivative used as an antineoplastic drug (trade name Velban) that disrupts cell division
For the past decade, a modified chemotherapy regimen consisting of cyclophosphamide, vincristine, procarbazine and prednisone (COPP), together with adriamycin, bleomycin and vinblastine (ABV) has been used to treat patients with HD.
Naturally occurring chemicals in obscure plants and animals have been spun into various life-saving drugs; perhaps the most famous is the rosy periwinkle, native only to Madagascar, from which we took the compounds vincristine and vinblastine to fight lymphoma and breast cancer.
—Cancer patient; presence of vinblastine and prednisone in significant quantities, traces of etoposide.
On October 7, 1974, Cleland took the gamble: he enrolled as “patient zero” for BVP, the acronym for a new regimen containing bleomycin, vinblastine, and cisplatin abbreviated P for “platinum”.
It turns out the pink-flowering plant has anticancer properties, and is now used to make the medicines vincristine and vinblastine.
Vincristine and vinblastine, two of our most successful cancer treatments, are derived from the rosy periwinkle tree, native to southern Madagascar.
Tropical plants such as the rosy periwinkle have given us two of our most powerful weapons against cancer—vincristine and vinblastine.
For example, grapefruit juice can reduce the absorption of the allergy medication fexofenadine (Allegra); digoxin, which is used to treat congestive heart failure; losartan (Cozaar), used to control blood pressure; and the anticancer drug vinblastine.
This herbaceous plant, native to South-eastern Madagascar, is a source of over 75 alkaloids, two of which, vincristine and vinblastine, are used to treat childhood leukemia and Hodgkin's disease, with a significant success rate.
(Catharanthus roseus) is a source of at least 60 alkaloids, of which the two important alkaloids, vincristine and vinblastine, have revolutionized the treatment of childhood leukemia and hodgkin's disease.
Wordnik is becoming a not-for-profit! Read our announcement here.