American Heritage® Dictionary of the English Language, Fourth Edition
- n. A highly toxic, immunosuppressive, antineoplastic drug, C7H15Cl2N2P, used in the treatment of Hodgkin's disease, lymphoma, and certain other forms of cancer, such as leukemia and breast cancer.
“Cytochrome P450-based suicide gene therapy for cancer using prodrugs such as cyclophosphamide (CPA) increases anti-tumor activity, both directly and via a bystander killing mechanism.”
“However, known carcinogens include alcoholic beverages, estrogen treatments for menopause symptoms, birth control pills, certain viruses and parasites, and even some drugs used to treat cancer, such as cyclophosphamide and tamoxifen.”
“For the past decade, a modified chemotherapy regimen consisting of cyclophosphamide, vincristine, procarbazine and prednisone (COPP), together with adriamycin, bleomycin and vinblastine (ABV) has been used to treat patients with HD.”
“This modified regimen contained less cyclophosphamide and procarbazine, agents known to impair fertility.”
“It is important to drink as much fluid as possible up to 2 liters on the days when cyclophosphamide is given, to help prevent irritation.”
“In the second study, which was done in Germany, 1,948 patients were randomized to receive epirubicin and cyclophosphamide (Cytoxan) followed by docetaxel (Taxotere), with or without bevacizumab (Avastin).”
“When a 12-year-old boy from Illinois with ALL arrived at St. Jude in 2001, Pui administered everything but the kitchen sink: the drugs prednisone, vincristine, daunorubicin, and asparaginase, followed by cyclophosphamide, cytarabine, and mercaptopurine.”
“For women, alkylating agents such as cyclophosphamide Cytoxan lead to the highest incidence of ovarian failure.”
“Final report on the evaluation of four toxic chemicals in an In Vivo/In Vitro toxicological screen -- acrylamide, chlordecone, cyclophosphamide, and diethylstilbestrol by Joellen Lewtas”
“Groups of mice given a single intraperitoneal injection of 200 mg cyclophosphamide per kg body weight served as the positive controls.”
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