from The American Heritage® Dictionary of the English Language, 4th Edition
- n. An alkaloid, C46H56N4O10, obtained from the Madagascar periwinkle and used as an antineoplastic drug for a variety of neoplasms.
from Wiktionary, Creative Commons Attribution/Share-Alike License
- n. A particular drug used in chemotherapy.
from WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.
- n. periwinkle plant derivative used as an antineoplastic drug (trade name Oncovin); used to treat cancer of the lymphatic system
The name vincristine comes from vinca, the Latin word for “bind.”
The vincristine was a powerful anti-cancer drug which was going to be used for Johnny, a patient on the ward with nephroblastomaa malignant tumour of the kidney.
Every time I treat a cat for cancer with a drug called "vincristine" I am grateful to the shaman that discovered the plant and the pharmacy company scientists that refined it into a useful drug.
For the past decade, a modified chemotherapy regimen consisting of cyclophosphamide, vincristine, procarbazine and prednisone (COPP), together with adriamycin, bleomycin and vinblastine (ABV) has been used to treat patients with HD.
Naturally occurring chemicals in obscure plants and animals have been spun into various life-saving drugs; perhaps the most famous is the rosy periwinkle, native only to Madagascar, from which we took the compounds vincristine and vinblastine to fight lymphoma and breast cancer.
Yet, I was comforted when I discovered that one of these drugs, vincristine, was actually derived from Africa's rosy periwinkle.
It turns out the pink-flowering plant has anticancer properties, and is now used to make the medicines vincristine and vinblastine.
The next regimen they would try would be a combination of all four drugs: vincristine, amethopterin, mercaptopurine, and prednisone.
The high doses of vincristine caused such severe collateral nerve damage that she was left with a permanent burning sensation in her legs and fingers.
On one side of the board was a list of cytotoxic drugs—Cytoxan, vincristine, procarbazine, methotrexate.
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