Definitions
from The American Heritage® Dictionary of the English Language, 4th Edition
- n. Any of a series of open chain hydrocarbons with a carbon-carbon triple bond and the general formula CnH2n-2.
from Wiktionary, Creative Commons Attribution/Share-Alike License
- n. A hydrocarbon containing at least one carbon–carbon triple bond.
from WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.
- n. a colorless flammable gas used chiefly in welding and in organic synthesis
Etymologies
from The American Heritage® Dictionary of the English Language, 4th Edition
Examples
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Follow the leader: the use of leader peptides to guide natural product biosynthesis Rapid behavior-based identification of neuroactive small molecules in the zebrafish Capture and release of alkyne-derivatized glycerophospholipids using cobalt chemistry Domino access to highly substituted chromans and isochromans from carbohydrates
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Since its introduction in 2001 by the Nobel laureate chemist Barry Sharpless of the Scripps Research Institute, the copper-catalyzed azide-alkyne reaction has proven extremely valuable for attaching small molecular probes to various biomolecules in a test tube or on fixed cells.
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Click chemistry is best known for a copper-catalyzed azide-alkyne reaction that makes it possible for certain chemical building blocks to "click" together in an irreversible linkage, analagous to the snapping together of Lego blocks.
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Slide 3: Unsaturated Hydrocarbons Unsaturated hydrocarbon: contains one or more x carbon-carbon double or triple bonds Alkene: contains a carbon-carbon double bond x and has the general formula CnH2n H H C C H H Ethylene (an alkene) Alkyne: HC CH a carbon-carbon triple bond and contains x has the general formula CnH2n-2 Acetylene (an alkyne)
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That first peptide - which is about a third of the length of the final capture agent the scientists are trying to make - is then isolated, purified, and modified on one end by the addition of a chemical group called an alkyne.
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The alkyne group on the added peptide can potentially chemically react with the azide group of the library's peptides, to create a new peptide that is now two segments long.
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The two-segment-long peptide then is isolated and purified, "and then we modify the end of that with an alkyne and add it back to the library to produce a three-segment peptide, which is long enough to be both selective for and specific to the target protein," Dr. Heath said.
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The supernatants were then treated with the alkyne - or azide-conjugated biotin-tags, and click chemistry was used to label the targets of the 4-BPB click derivatives.
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The propargyl (alkyne) and azido groups are bioorthogonal reaction partners.
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List of top 100 targets identified by LC-MS/MS using 4-PPB, the alkyne click derivative of
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