from The American Heritage® Dictionary of the English Language, 4th Edition

  • Below; beneath; under: hypodermic.
  • Less than normal; deficient: hypoesthesia.
  • In the lowest state of oxidation: hypoxanthine.

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • Below; beneath; under.
  • Deficient; less than normal.
  • A name for oxoacid and oxyanions with a low amount of oxygen.

from the GNU version of the Collaborative International Dictionary of English

  • A prefix signifying a less quantity, or a low state or degree, of that denoted by the word with which it is joined, or position under or beneath.
  • A prefix denoting that the element to the name of which it is prefixed enters with a low valence, or in a low state of oxidization, usually the lowest, into the compounds indicated.


from The American Heritage® Dictionary of the English Language, 4th Edition

Greek hupo-, from hupo, under, beneath; see upo in Indo-European roots.

from Wiktionary, Creative Commons Attribution/Share-Alike License

From Ancient Greek ὑπο- (hypo-), combining form of ὑπό (hypó, "under"). Compare sub-.


  • You also may experience hypo- or hyper-pigmentation, where patches of your skin may appear lighter or darker than surrounding areas.

    Glenn D. Braunstein, M.D.: Tattoos: Inks Raise New Health Concerns About Age-Old Designs

  • Some scars present as post-inflammatory hypo- or hyperpigmentation PIH.

    Simple Skin Beauty

  • Dark skin types (Fitzpatrick Types 5 and 6) should stay away from IPL and pigment-targeting lasers such as the Nd:YAG, since they can cause postinflammatory hypo- or hyperpigmentation (PIH).

    Simple Skin Beauty

  • Darker skin and Asian complexions Fitzpatrick Types 3 to 6 are prone to ill effects—primarily postinflammatory hypo- or hyperpigmentation or PIH—from stronger peels, especially melanotoxic TCA.

    Simple Skin Beauty

  • The location below the center of a nuclear detonation is, strictly speaking, the hypocenter, with the Greek hypo- meaning “under”; that word was soon overtaken by epicenter the Greek prefix epi- means “on, over”, the outbreaking point on the earth’s surface above the focus of an earthquake.

    The Right Word in the Right Place at the Right Time


Log in or sign up to get involved in the conversation. It's quick and easy.