from The American Heritage® Dictionary of the English Language, 4th Edition

  • n. A membrane-bound vesicle found in a cell by an inward folding of the cell membrane to hold foreign matter taken into the cell by phagocytosis.

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. A membrane-bound vacuole within a cell containing foreign material captured by phagocytosis.


phago- + -some (Wiktionary)


  • The environment in the phagosome of macrophages infected with the mutant differed from the environment of vacuoles with M. hominissuis wild-type in the concentration of zinc, manganese, calcium and potassium.

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  • This mutant, in contrast to the wild-type bacterium, was shown both to have impaired the ability to replicate within macrophages and to have prevented phagosome/lysosome fusion.

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  • Based on the results, it was hypothesized that the phagosome environment and vacuole membrane of the wild-type bacterium might differ from the mutant.

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  • TRPV2 was recruited to the nascent phagosome and depolarized the plasma membrane.

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  • The mammalian orthologues of SAND-1, namely Mon1a and Mon1b, were similarly required for phagosome maturation.

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  • Moreover, a Mon1-Ccz1 complex (but not either protein alone) could bind Rab7 and could also influence Rab7 activation, suggesting Mon1-Ccz1 as an important link in progression from the Rab5-positive stage to the Rab7-positive stage of phagosome maturation.

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  • Urease activity which was shown to be critical for M. tuberculosis survival in phagosome is dependent on Nickel, while Vitamin B12 biosynthesis which is a Cobalt dependent process is important for

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  • Gavrilin MA, Bouakl IJ, Knatz NL, Duncan MD, Hall MW, et al. (2006) Internalization and phagosome escape required for Francisella to induce human monocyte IL-1beta processing and release.

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  • "High content phenotypic cell-based visual screen identifies Mycobacterium tuberculosis acyltrehalose-containing glycolipids involved in phagosome remodeling", PLoS Pathogens - latest science and technology news stories

  • The team identified ten distinct mutants, only one of which had previously been shown to play a part in phagosome maturation arrest. - latest science and technology news stories


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