from The American Heritage® Dictionary of the English Language, 4th Edition
- n. Any of a group of DNA-containing viruses, including those that cause smallpox, cowpox, and other poxlike diseases in vertebrates.
from Wiktionary, Creative Commons Attribution/Share-Alike License
- n. Any of a group of DNA viruses, of the family Poxviridae, that cause pox diseases in vertebrates
from WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.
- n. any of a group of viruses that can cause pox diseases in vertebrates
Sorry, no etymologies found.
Over roughly the past decade, the CDC has been called to retrieve the remains of a man covered with smallpox lesions whose coffin was unearthed during construction near Louisville, Ky., as well as suspicious-looking scabs in a library book in New Mexico and a museum in Arkansas, says Inger Damon, chief of the CDC's poxvirus and rabies branch.
The smallpox vaccine is made using a poxvirus that infects cows (cowpox or vaccinia).
So far the most promising of these vaccines has been one using another poxvirus -- canarypox -- to deliver HIV recombinants (See Table 2).
Other vaccine trials using the poxvirus vaccinia as a vector to deliver live recombinant HIV (based on glycoprotein 160) have been found safe, and have stimulated partial immunity to HIV.
CV-301 originates from the same poxvirus technology platform as PROSTVAC
To overcome this poor responsiveness, recombinant poxvirus vectors, including vaccinia, fowlpox and modified vaccinia Ankara (MVA), can be genetically engineered to express one or more tumor-associated antigens to greatly enhance the immune system's ability to recognize and destroy cancer cells bearing any of the targeted antigens. ® and CV-301 are prime-boost vaccines, sequentially combining two different poxviruses (vaccinia and fowlpox).
British research has found that the vaccinia poxvirus spreads infection by jumping from one cell to another before it finds an uninfected cell.
The attachment of a poxvirus particle to a cell triggers a multitude of incompletely understood signaling events inside the cell.
"It (the discovery) helps us understand how poxvirus causes disease by evading the immune response," Deng said.
If this breakthrough is made, it will help advance the finding of the structure of the poxvirus protein, which could lead to the development of medication and other items necessary to fight poxviruses, Krumm said.