ribonucleotide love


from The American Heritage® Dictionary of the English Language, 4th Edition

  • n. A nucleotide that contains ribose as its sugar and is a component of RNA.

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. Any nucleotide having ribose as its sugar


from The American Heritage® Dictionary of the English Language, 4th Edition

ribo(se) + nucleotide.


  • The protozoal enzymes consequently convert allopurinol ribonucleotide to the adenylate analog, 4-aminopyrazolopyrimidine ribonucleotide, which is then converted to a di - and tri-phosphate and incorporated in RNA (93), (94), (98), (100).

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  • Once the particles find the cancer cell and get inside, they break down, releasing small interfering RNAs or siRNAs that block a gene that makes a cancer growth protein called ribonucleotide reductase [

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  • The overall shape of a sequence of the molecules in a particular stretch of DNA is such that it combines with a molecule (or collection of molecules) that we designate "RNA polymerase", to form a holoenzyme that catalyzes the addition of a particular ribonucleotide to a string of nucleotides, which we call "RNA".

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  • In this pathway, the complete ribonucleotide structure forms without using free sugar and nucleobase molecules as intermediates.

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  • This central insight, combined with a series of additional innovations, provides a remarkably efficient solution to the problem of prebiotic ribonucleotide synthesis.

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  • For 40 years, efforts to understand the prebiotic synthesis of the ribonucleotide building blocks of RNA have been based on the assumption that they must have assembled from their three molecular components: a nucleobase (which can be adenine, guanine, cytosine or uracil), a ribose sugar and phosphate.

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  • But Powner et al. 2 revive the prospects of the 'RNA first' model by exploring a pathway for pyrimidine ribonucleotide synthesis in which the sugar and nucleobase emerge from a common precursor (Fig. 1b).

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  • A different colored balloon for every ribonucleotide and a puff of smoke for every pyrophosphate cleavage ... science entertainment at its best.

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  • It would have been reasonable for me to try to work out the enzymology of ribonucleotide reduction after graduating.

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  • Together with Nancy, we later identified the key regulatory regions in the 3 'untranslated region of ribonucleotide reductase and cyclin A mRNAs that are necessary for translational masking.

    Tim Hunt - Autobiography


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