from The American Heritage® Dictionary of the English Language, 4th Edition
- n. A steroid hormone secreted by the adrenal cortex that regulates the salt and water balance in the body.
from Wiktionary, Creative Commons Attribution/Share-Alike License
- n. A mineralocorticoid hormone, secreted by the adrenal cortex, that regulates the balance of sodium and potassium in the body.
from WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.
- n. a corticosteroid hormone that is secreted by the cortex of the adrenal gland; regulates salt (sodium and potassium) and water balance
Pfizer's pill failed because it unexpectedly increased levels of a hormone called aldosterone, linked to fatty plaque buildup and high blood pressure.
Dr. Michael Alderman, a blood pressure researcher at Albert Einstein College of Medicine and editor of the American Journal of Hypertension, said in an email, The problem with reducing sodium enough to change blood pressure is that it has other effects -- including increasing insulin resistance, increasing sympathetic nerve activity, and activating the renin-angiotensin system and increasing aldosterone secretion.
If one lowers sodium intake to lower blood pressure, this change in sodium activates several systems including the renin-angiotensin aldosterone system that conserve sodium, and those systems are implicated in disease processes such as damaging the arterial wall and kidneys, Staessen says,This study may apply to Americans of white European descent, but it might less applicable to blacks because they are believed to be more salt sensitive, he says.
There was no increase in blood pressure and no increase in levels of aldosterone or cortisol, two hormones that were elevated in the earlier Pfizer torcetrapib trial.
The Big C Gets Its Own Biography Brain Scan Reveals Source of Anxiety Triathlons Keep 70-Year-Old Neurosurgeon Young Scientists now believe that torceptrapib had deleterious effects on the heart because it raised blood pressure and increased levels of substances called electrolytes and a hormone called aldosterone.
Bile contains bile salts, which emulsify (break down) fats in the digestive tract and aid in the absorption of fat molecules as well as the fat soluble vitamins, Vitamin A, Vitamin D, Vitamin E and Vitamin K. Cholesterol is an important molecule for the synthesis of Vitamin D and the steroid hormones, including the adrenal gland hormones; cortisol and aldosterone as well as the sex hormones progesterone, estrogen, and testosterone.
The study also found that lead exposure was associated with a decrease in circulating aldosterone levels.
Licorice is a time-honored remedy for arthritis due to its antiinflammatory properties: It stimulates the production of two steroids, cortisone and aldosterone, which help reduce inflammation.
The increased production of aldosterone can result in a rise in blood pressure.
Fortunately for the person who's eaten all that salt, aldosterone escape and ANP will put a stop to his increasing blood volume before he bursts.
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